| Endothelin ETA and ETB receptors mediate vasoconstriction and prostanoid release in the isolated kidney of the rat. | |
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MedLine Citation:
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PMID: 8112405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 or sarafotoxin 6c (10(-12) to 10(-9) M) induced concentration-dependent increases in perfusion pressure in the isolated perfused kidney of the rat, and increased the release of 6-keto-prostaglandin F1 alpha, prostaglandin E2 and prostaglandin F2 alpha. The pressor effects of endothelin-1 were partially antagonised by BQ-123 (10(-6) M) and more strongly so by the endothelin ETA/B receptor non-selective antagonist PD 145065 (10(-6) M). PD 145065, but not BQ-123, also completely blocked the pressor effects of sarafotoxin 6c. The releases of prostanoids induced by endothelin-1 were greatly reduced by infusion of either BQ-123 or PD 145065, whereas PD 145065, but not BQ-123, strongly antagonised the releases induced by sarafotoxin 6c. These results indicate that the vasoconstrictions and the prostanoid releases induced by the endothelin/sarafotoxin peptides are mediated by the activation of both endothelin ETA and endothelin ETB receptors in the isolated perfused kidney of the rat. |
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Authors:
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T D Warner; B Battistini; G H Allcock; J R Vane |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 250 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-31 Completed Date: 1994-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: IM |
Affiliation:
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William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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metabolism Amino Acid Sequence Animals Dinoprost / metabolism Dinoprostone / metabolism Endothelins / antagonists & inhibitors, pharmacology Kidney / blood supply, drug effects, metabolism* Male Molecular Sequence Data Oligopeptides / pharmacology Peptides, Cyclic / pharmacology Prostaglandins / metabolism* Rats Rats, Wistar Receptor, Endothelin A Receptor, Endothelin B Receptors, Endothelin / antagonists & inhibitors, physiology* Vasoconstriction* / drug effects Vasoconstrictor Agents / pharmacology Viper Venoms / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Oligopeptides; 0/Peptides, Cyclic; 0/Prostaglandins; 0/Receptor, Endothelin A; 0/Receptor, Endothelin B; 0/Receptors, Endothelin; 0/Vasoconstrictor Agents; 0/Viper Venoms; 0/sarafotoxins s6; 136553-81-6/cyclo(Trp-Asp-Pro-Val-Leu); 153049-49-1/PD 145065; 363-24-6/Dinoprostone; 551-11-1/Dinoprost; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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