Document Detail


Endothelin-1 and unstable angina: effect of either endothelin ET(A) or ET(B) receptor antagonism in a locally injured canine coronary artery.
MedLine Citation:
PMID:  9543239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of endogenous endothelin-1 in variant angina was investigated using two endothelin receptor antagonists: LU 135252 (ET(A)) and BQ 788 (ET(B)). Cyclic flow reductions were induced in a coronary artery of mongrel dogs by combining critical stenosis with endothelial injury. One hour after induction of cyclic coronary flow reductions the dogs were randomized to intravenous treatment with either saline, or LU 135252 (10 mg kg(-1)), or BQ 788 (0.1 mg kg(-1)). Cyclic coronary flow reductions were monitored for two hours after drug and remained constant in controls as well as after BQ 788. LU 135252 reduced the number of cyclic coronary flow reductions significantly (about 50%) without effects on hemodynamics or hemostasis.
Authors:
M Kirchengast; S Hergenröder; S Schult; K Münter; K Rübsamen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  341     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2004-01-20    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Preclinical Cardiology, Knoll AG, Ludwigshafen, Germany. michael.kirchengast@knoll-ag.de
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MeSH Terms
Descriptor/Qualifier:
Angina, Unstable / drug therapy,  metabolism*
Animals
Coronary Circulation / drug effects*
Coronary Vessels / drug effects*,  injuries
Dogs
Endothelin-1 / drug effects*,  metabolism
Endothelium, Vascular / drug effects,  injuries
Oligopeptides / pharmacology,  therapeutic use
Phenylpropionates / pharmacology,  therapeutic use
Piperidines / pharmacology,  therapeutic use
Pyrimidines / pharmacology,  therapeutic use
Receptor, Endothelin B
Receptors, Endothelin / antagonists & inhibitors*,  drug effects
Chemical
Reg. No./Substance:
0/BQ 788; 0/Endothelin-1; 0/LU 135252; 0/Oligopeptides; 0/Phenylpropionates; 0/Piperidines; 0/Pyrimidines; 0/Receptor, Endothelin B; 0/Receptors, Endothelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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