| Endothelin-1 stimulates sphincter of Oddi motility and decreases trans-sphincteric flow: a possible mechanism contributes to cholestasis in disease states. | |
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MedLine Citation:
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PMID: 12846727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 (ET-1) is a potent stimulator of gallbladder contractility. Its role in modulation of sphincter of Oddi (SO) motility and trans-sphincteric flow (TSF) has not been evaluated. To characterize the effects of ET-1 on SO motility and TSF, 10 anaesthetized Australian possums (in vivo, n = 6) were given graded doses of ET-1 (5-200 pmol kg-1) via closed intra-arterial injection. Blood pressure, TSF and SO motility (basal pressure, phasic amplitude, contraction frequency) were analysed. For in vitro studies, eight SO rings were subjected to 10-12-10-7 mol L-1 cumulative concentrations of ET-1 in organ bath and SO motility was measured. Data are expressed as mean +/- SEM. Statistical analysis used anova. ET-1 induced a dose-related increase in blood pressure with a maximal increase of 37.5 +/- 2.5 mmHg at 200 pmol kg-1, (P < 0.001). ET-1 also increases SO basal pressure (P < 0.001) and contraction frequency (P < 0.0001). However, the contraction amplitude was not significantly affected. ET-1 decreased TSF in a dose-related manner (P < 0.001) with cessation of TSF at the highest dose (P < 0.001). In vitro studies showed a significant increase in mean SO motility index, and frequency of contractions at higher ET-1 concentrations (10-9-10-7 mol L-1). ET-1 is a potent stimulator of SO motility resulting in a reduction in TSF. |
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Authors:
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J W C Chen; A C Schloithe; J Toouli; G T P Saccone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 15 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-08 Completed Date: 2003-09-08 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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Department of General and Digestive Surgery, Centre for Digestive Sciences, Flinders University, Flinders Medical Centre, Australia. john.chen@flinders.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholestasis / etiology Endothelin-1 / pharmacology* Female Gallbladder / drug effects, physiology Gastrointestinal Motility / drug effects*, physiology Male Opossums / physiology* Organ Culture Techniques Sphincter of Oddi / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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