| Endothelin-1 stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium. II. | |
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MedLine Citation:
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PMID: 1725326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of endothelin-1 (ET-1) on rat cardiac myocytes cultured in a serum-free medium was determined. Cardiac myocytes cultured in our medium showed an increased rate of protein synthesis, morphological size, contraction rate, and Ca2+ uptake when ET-1 was added. These actions of ET-1 were inhibited by a protein kinase C inhibitor, H-7. Among these four phenomena, contraction and Ca2+ uptake were inhibited by a Ca2+ channel blocker, nicardipine. Therefore, it is likely that the signal for ET-1 to induce these phenomena is transduced by kinase C, and Ca2+ uptake is related to maintaining a high contraction rate. |
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Authors:
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T Suzuki; H Hoshi; H Sasaki; Y Mitsui |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 17 Suppl 7 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-12 Completed Date: 1992-05-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S182-6 Citation Subset: IM |
Affiliation:
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Bio-Science Laboratory, Inc., Yamagata, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Animals, Newborn Calcium / metabolism Culture Media Endothelins / antagonists & inhibitors, pharmacology* Heart / drug effects Heart Rate / drug effects Hypertrophy Isoquinolines / pharmacology Male Muscle Proteins / biosynthesis Myocardial Contraction / drug effects* Myocardium / cytology*, enzymology, metabolism Nicardipine / pharmacology Piperazines / pharmacology Protein Kinase C / antagonists & inhibitors, metabolism Rats Rats, Inbred Strains Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Endothelins; 0/Isoquinolines; 0/Muscle Proteins; 0/Piperazines; 55985-32-5/Nicardipine; 7440-70-2/Calcium; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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