| Endothelin-1 and prostaglandin E2 levels increase in patients with burns. | |
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MedLine Citation:
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PMID: 7874342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endothelin-1 (ET-1), a powerful vasoconstrictor, is a 21 amino acid peptide produced by endothelium. It negatively affects pulmonary, cardiac, hepatic, and renal function. It also constricts bronchial and gut smooth muscle. This peptide also stimulates monocytes to produce prostaglandin E2 (PGE2), tumor necrosis factor, interleukin-6 and 8, and substances that stimulate neutrophil superoxide production. Plasma levels of ET-1 also increase in shock, low flow states, ischemia, and sepsis. STUDY DESIGN: Fourteen patients between the ages of seven and 72 years were admitted to the Bridgeport Hospital Burn Unit and resuscitated with a modified Parkland formula. Plasma was drawn on admission, at 12, 24, and 48 hours. Endothelin-1 and PGE2 were measured by radioimmunoassay. RESULTS: Endothelin-1 levels increased ten- to 20-fold in all patients. Prostaglandin E2 levels increased five- to 40-fold in all patients. There was no correlation between plasma ET-1 or PGE2 levels with either size of burn, inhalation injury, patient age, organ dysfunction, or survival in this small study of early burn injury. CONCLUSIONS: The increased plasma ET-1 response in patients with burns may have a role in the genesis of the systemic response to burns. This peptide may also activate monocyte production of PGE2 and other mediators of the systemic inflammatory response syndrome. This study was done to measure ET-1 and PGE2 levels in patients with burns greater than 20 percent of the body surface area on admission, at 12, 24, and 48 hours. The correlations between severity of burn, ET-1 levels, and PGE2 production were also assessed. |
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Authors:
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M Huribal; M E Cunningham; M L D'Aiuto; W E Pleban; M A McMillen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Surgeons Volume: 180 ISSN: 1072-7515 ISO Abbreviation: J. Am. Coll. Surg. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-03-31 Completed Date: 1995-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431305 Medline TA: J Am Coll Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 318-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Yale University School of Medicine, Bridgeport, CT. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Blood Pressure / physiology Body Surface Area Burns / blood*, pathology, physiopathology, urine Burns, Inhalation / blood Child Dinoprostone / blood* Endothelins / blood* Humans Middle Aged Monocytes / metabolism Survival Rate Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 363-24-6/Dinoprostone |
| Comments/Corrections | |
Comment In:
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J Am Coll Surg. 1995 Dec;181(6):583-4
[PMID:
7582238
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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