Document Detail

Endothelin-1 potentiates the in vitro contractile response of pregnant human myometrium to oxytocin.
MedLine Citation:
PMID:  7755074     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was designed to test the hypothesis that endothelin-1 pretreatment of human myometrium at subcontractile doses in vitro will enhance the contractile response to oxytocin. STUDY DESIGN: In vitro contractile oxytocin dose-response curves were generated by use of myometrial strips collected from nonpregnant women (n = 7), pregnant patients at elective cesarean section (n = 7), and patients in active labor (n = 7) in the presence or absence of 10(-9) mol/L endothelin-1. Contractile responses were analyzed by on-line computer, and data were normalized to the maximum response to potassium. RESULTS: Pretreatment with endothelin-1 significantly increased the maximal contractile response of pregnant myometrium (p < 0.01 compared with control). In marked contrast myometrium from nonpregnant patients was unaffected by endothelin-1 pretreatment. Values for the two-point discrimination and Hill coefficient were not different among the treatment groups. CONCLUSION: Endothelin-1 potentiates the oxytocin response of myometrium from pregnant but not nonpregnant women. We speculate that a high circulating level of a uterotonin-like oxytocin may not be necessary to initiate labor. The synergistic interaction between different uterotonins may be sufficient.
G J Valenzuela; C W Hewitt; C A Ducsay
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  172     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-19     Completed Date:  1995-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1573-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, San Bernardino County Medical Center, CA 92415-0935, USA.
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MeSH Terms
Analysis of Variance
Dose-Response Relationship, Drug
Drug Synergism
Endothelins / pharmacology*
Myometrium / drug effects*,  physiology
Oxytocin / pharmacology*
Pregnancy / physiology*
Uterine Contraction / drug effects*
Reg. No./Substance:
0/Endothelins; 50-56-6/Oxytocin

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