Document Detail

Endothelin-1 is not involved in serotonin-induced coronary spasm in a swine model.
MedLine Citation:
PMID:  7585805     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The role of endothelin-1 (ET-1) in the pathogenesis of coronary artery spasm is not well understood. We aimed to determine if ET-1 is involved in serotonin-induced coronary spasm in the swine model. METHODS: In 10 miniature pigs, a segment of the left anterior descending coronary artery was denuded and irradiated with X-ray. Three months after endothelial denudation, coronary vasomotion was assessed in vivo by quantitative arteriography. RESULTS: Intracoronary serotonin at 10 micrograms/kg provoked coronary spasm (augmented narrowing of the luminal diameter) at the denuded site (diameter reduction 93 +/- 4%) but not at the non-denuded control site (19 +/- 4%, P < 0.01) associated with ST segment elevation in the region perfused by the denuded artery. Intracoronary administration of ET-1 at 25 ng/kg caused mild vasoconstriction of the denuded (26 +/- 4) and non-denuded site (16 +/- 3%, n.s.), but provoked ST segment elevation in the regions perfused by both the denuded and non-denuded arteries. The treatment with an endothelin antagonist (BQ123 0.1 mg/kg) significantly attenuated coronary vasoconstriction and ST segment elevation evoked with ET-1, but did not alter serotonin-induced vasoconstriction either at the denuded or control site. CONCLUSIONS: The results of this study suggest that endogenous ET-1 may not be involved in the pathogenesis of serotonin-induced coronary spasm in our swine model.
T Fukai; K Egashira; K Numaguchi; H Hata; T Takahashi; H Kasuya; M Sakata; H Shimokawa; A Takeshita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  30     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan.
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MeSH Terms
Coronary Angiography
Coronary Vasospasm / blood,  etiology*,  pathology
Coronary Vessels / drug effects*,  pathology
Endothelins / blood,  pharmacology*
Peptides, Cyclic / pharmacology
Receptors, Endothelin / antagonists & inhibitors
Serotonin / pharmacology*
Swine, Miniature
Vasoconstriction / drug effects
Reg. No./Substance:
0/Endothelins; 0/Peptides, Cyclic; 0/Receptors, Endothelin; 136553-81-6/cyclo(Trp-Asp-Pro-Val-Leu); 50-67-9/Serotonin

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