Document Detail

Endothelin-1 levels in infants with pulmonary hypertension receiving extracorporeal membrane oxygenation.
MedLine Citation:
PMID:  10503184     Owner:  NLM     Status:  MEDLINE    
We studied the possibility of an etiological role for endothelin-1 (ET-1) in the development of persistent pulmonary hypertension of the newborn (PPHN). Ten infants with severe PPHN requiring extracorporeal membrane oxygenation (ECMO) were studied. Pre and post pulmonary blood samples were obtained on commencing ECMO and on recovery. The samples were analyzed by radio-immunoassay. The infants with PPHN requiring ECMO had a significantly higher mean ET-1 concentration (21.1 pmol/l, S. D. 3.59) than a group of healthy controls (16.6 pmol/l, S. D. 4.44); however 8 of our 10 infants had individual ET-1 levels within our reference range for healthy newborns. Pre and post pulmonary ET-1 levels did not differ significantly and there was no evidence of a decline in ET-1 levels with resolution of PPHN. Pulmonary overproduction of ET-1 does not appear to be the cause of PPHN, although the endothelin system may still play a role in the pathophysiology of PPHN, probably mediated through changes in receptor expression.
P D Macdonald; R D Paton; R W Logan; C H Skeoch; C F Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  27     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-05     Completed Date:  1999-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  216-20     Citation Subset:  IM    
Department of Neonatal Pediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, U.K.
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MeSH Terms
Carotid Arteries
Endothelin-1 / blood*
Extracorporeal Membrane Oxygenation*
Infant, Newborn
Jugular Veins
Lung / metabolism
Persistent Fetal Circulation Syndrome / blood,  therapy*
Reference Values
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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