| Endothelin-1 levels in infants with pulmonary hypertension receiving extracorporeal membrane oxygenation. | |
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MedLine Citation:
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PMID: 10503184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the possibility of an etiological role for endothelin-1 (ET-1) in the development of persistent pulmonary hypertension of the newborn (PPHN). Ten infants with severe PPHN requiring extracorporeal membrane oxygenation (ECMO) were studied. Pre and post pulmonary blood samples were obtained on commencing ECMO and on recovery. The samples were analyzed by radio-immunoassay. The infants with PPHN requiring ECMO had a significantly higher mean ET-1 concentration (21.1 pmol/l, S. D. 3.59) than a group of healthy controls (16.6 pmol/l, S. D. 4.44); however 8 of our 10 infants had individual ET-1 levels within our reference range for healthy newborns. Pre and post pulmonary ET-1 levels did not differ significantly and there was no evidence of a decline in ET-1 levels with resolution of PPHN. Pulmonary overproduction of ET-1 does not appear to be the cause of PPHN, although the endothelin system may still play a role in the pathophysiology of PPHN, probably mediated through changes in receptor expression. |
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Authors:
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P D Macdonald; R D Paton; R W Logan; C H Skeoch; C F Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 27 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 1999 |
Date Detail:
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Created Date: 1999-11-05 Completed Date: 1999-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 216-20 Citation Subset: IM |
Affiliation:
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Department of Neonatal Pediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carotid Arteries Endothelin-1 / blood* Extracorporeal Membrane Oxygenation* Humans Infant, Newborn Jugular Veins Lung / metabolism Persistent Fetal Circulation Syndrome / blood, therapy* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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