Document Detail


Endothelin-1 and the kidney--beyond BP.
MedLine Citation:
PMID:  22670597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since its discovery over 20 years ago endothelin-1 (ET-1) has been implicated in a number of physiological and pathophysiological processes. Its role in the development and progression of chronic kidney disease (CKD) is well established and is an area of ongoing intense research. There are now available a number of ET receptor antagonists many of which have been used in trials with CKD patients and shown to reduce BP and proteinuria. However, ET-1 has a number of BP-independent effects. Importantly, and in relation to the kidney, ET-1 has clear roles to play in cell proliferation, podocyte dysfunction, inflammation and fibrosis, and arguably, these actions of ET-1 may be more significant in the progression of CKD than its prohypertensive actions. This review will focus on the potential role of ET-1 in renal disease with an emphasis on its BP-independent actions.
Authors:
Neeraj Dhaun; David J Webb; David C Kluth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of pharmacology     Volume:  167     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-25     Completed Date:  2013-02-12     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  720-31     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
Affiliation:
Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. bean.dhaun@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Endothelin-1 / physiology*
Hemodynamics
Humans
Kidney / physiology*
Kidney Diseases / physiopathology
Chemical
Reg. No./Substance:
0/Endothelin-1
Comments/Corrections

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