| Endothelin-1, interleukin-6, and interleukin-8 levels increase in patients with burns. | |
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MedLine Citation:
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PMID: 8889860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin is produced by injured or ischemic endothelium and causes monocyte production of interleukins-6 and 8 in vitro. Endothelin levels increase in patients with burn injuries, and we asked whether interleukin-6 and 8 levels increased in patients with burn injuries concurrently with endothelin. Fourteen patients with more than 20% body surface area burns were resuscitated to maintain urine output of 0.5 to 1.0 ml/kg/hr. Blood was drawn on admission and at 12, 24, and 48 hours. Endothelin was measured by radioimmunoassay, interleukins-6 and 8 were measured by enzyme-linked immunosorbent assay. Endothelin levels increased to 6.1 +/- 2.3 fmol on admission, 5.7 +/- 2.1 at 12 hours, 6.9 +/- 2.7 at 24 hours, and 6.4 +/- 2.7 at 48 hours (vs 0.5 in healthy controls). Interleukin-6 increased to 243 +/- 220 pg/ml on admission, 276 +/- 198 at 12 hours, 400 +/- 282 at 24 hours, and 379 +/- 274 at 48 hours (vs less than 50 in healthy controls). Interleukin-8 increased to 504 +/- 309 pg/ml on admission, 483 +/- 263 at 12 hours, 575 +/- 306 at 24 hours, and 698 +/- 667 at 48 hours (vs less than 50 in controls). Endothelin-1 and interleukin-6 and 8 levels increase in patients with burn injuries. Endothelin-mediated activation of monocytes that cause cytokine production may have clinical relevance in patients with burn injuries. |
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Authors:
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M A McMillen; M Huribal; M E Cunningham; R J Bala; W E Pleban; M L D'Aiuto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 17 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1996 Sep-Oct |
Date Detail:
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Created Date: 1997-02-10 Completed Date: 1997-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 384-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Yale University, Bridgeport, Connecticut, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Burns / metabolism*, pathology Endothelin-1 / analysis*, metabolism Humans Injury Severity Score Interleukin-6 / analysis*, metabolism Interleukin-8 / analysis*, metabolism Middle Aged Prognosis Radioimmunoassay Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Interleukin-6; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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