Document Detail

Endothelin-1-induced renal vasoconstriction is blunted by enalaprilat and enhanced by EDRF antagonist in awake normotensive rats.
MedLine Citation:
PMID:  1665404     Owner:  NLM     Status:  MEDLINE    
We attempt to elucidate the putative indirect mechanisms by which endothelin-1 affects mean blood pressure and renal blood flow in normotensive awake rats. Endothelin-1 (700 pg/kg, i.v.) induced a short-lasting decrease followed by a prolonged increase in mean blood pressure (from 113 +/- 4 to 92 +/- 4 mmHg at 30 sec, 132 +/- 7 mmHg at 10 min, and 129 +/- 6 mmHg at 30 min, p less than 0.01), and caused a profound and long-lasting fall in renal blood flow as measured by Doppler flowmeter technique (from 2.87 +/- 0.29 to 1.40 +/- 0.37 kHz at 30 sec, 1.77 +/- 0.32 kHz at 10 min and 2.10 +/- 0.45 kHz at 30 min, p less than 0.01). Neither the receptor antagonist of bradykinin D-Arg0-Hyp3-Thi5,8-DPhe7-bradykinin (30 micrograms/kg/min, i.v.) nor the antagonist of angiotensin II Sar1, Thr8-angiotensin II (4 micrograms/kg/min, i.v.) altered the changes in mean blood pressure and renal blood flow induced by endothelin-1. The antagonist of EDRF synthesis, NG-monomethyl-L-arginine (100 micrograms/kg/min, i.v.) enhanced the endothelin-1-induced increase in mean blood pressure (endothelin-1: 20 +/- 2 mmHg vs endothelin-1 + EDRF antagonist: 39 +/- 3 mmHg at 10 min, p less than 0.01) and decrease in renal blodo flow (endothelin-1: -40 +/- 4% vs endothelin-1 + EDRF antagonist: -73 +/- 3% at 10 min, p less than 0.01).2+ mediated by the blockade of angiotensin II formation.
P Madeddu; V Anania; P P Parpaglia; C Troffa; A Pazzola; A Soro; P Manunta; G Tonolo; M P Demontis; M V Varoni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  14     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-04-09     Completed Date:  1992-04-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  600-6     Citation Subset:  IM    
Clinica Medica and Farmacologia, University of Sassari, Italy.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Blood Pressure / drug effects
Enalaprilat / pharmacology*
Endothelins / pharmacology*
Kidney / blood supply*
Nitric Oxide / antagonists & inhibitors*
Rats, Inbred Strains
Renal Circulation / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Endothelins; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine; 84680-54-6/Enalaprilat

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