Document Detail

Endothelin-1 and functional tissue factor: a possible relationship with severity in primary pulmonary hypertension.
MedLine Citation:
PMID:  12644876     Owner:  NLM     Status:  MEDLINE    
Although dysfunctional endothelium, vasoconstriction, and in situ thrombosis are characteristics of primary pulmonary hypertension, the role that plasma vasomotor and coagulation factors play in this phenomenon are not completely understood. The aim of this work was to ascertain the diagnostic value of endothelin-1, thrombomodulin, tissue factor, and tissue factor pathway inhibitor, as well as their correlation with endothelial dysfunction in primary pulmonary hypertension patients. We analyzed the plasmatic concentration and chromogenic of the above-mentioned molecules using immunoenzymatic techniques. Patients were divided into responders and nonresponders on the basis of their hemodynamic response to a vasodilator trial. We found a continuous increase in endothelin-1 levels and a continuous decrease in functional tissue factor in the control group, responders, and nonresponders, respectively. Moreover, the patients showed a moderate decrease in thrombomodulin levels compared with the control group, without statistical significance. These results support a previous description of a decrease in thrombomodulin levels in primary pulmonary hypertension patients and suggests that an alteration of endothelin-1 and functional tissue factor could be related to a worsening of endothelial function and, indirectly, with the clinical severity of primary pulmonary hypertension.
María T Collados; Blanca Velázquez; José R Borbolla; Julio Sandoval; Felipe Massó; Luis F Montaño; Verónica Guarner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  18     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2003-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Centro de Investigación y Extensión en Ciencias de la Salud (CIECS), Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM), Apdo. 5091, Sucursal Tecnológico, 64849 Monterrey, NL, Mexico.
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MeSH Terms
Endothelin-1 / blood*
Endothelium, Vascular / physiopathology
Hypertension, Pulmonary / blood*,  physiopathology
Lipoproteins / analysis
Thrombomodulin / blood
Thromboplastin / analysis
von Willebrand Factor / analysis
Reg. No./Substance:
0/Endothelin-1; 0/Lipoproteins; 0/Thrombomodulin; 0/lipoprotein-associated coagulation inhibitor; 0/von Willebrand Factor; 9035-58-9/Thromboplastin

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