| Endothelin-1 excretion in urine in active pulmonary sarcoidosis and in other interstitial lung diseases. | |
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MedLine Citation:
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PMID: 8532958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 (ET-1) is a vasoactive, mitogenic peptide that is variably increased in Bronchoalveolar Lavage Fluid (BALF) and immunohistochemically found in lung tissue of patients with Interstitial Lung Disease (ILD). To assess if endogenous ET-1 production is increased in ILD we evaluated 24 hour (24h) urine excretion of ET-1 in 20 patients with ILD and 10 healthy age-matched controls (HC). Eight patients with active pulmonary sarcoidosis (S), 6 with idiopathic pulmonary fibrosis (IPF) and 6 with focal lung fibrosis due to inactive pulmonary tuberculosis (hTB) were studied. Plasma ET-1 levels (ET-1pl, pg/ml) and 24h ET-1 levels in urine (ET-1ur, ng/24h) were measured by a specific radio-immunoassay. Determinations of ET-1p1 and ET-1ur were repeated in S and IPF patients after 30 days of prednisone (0.75 mg/kg/day) treatment. ET-1p1 concentrations were not different between HC (5.34 +/- 0.48), S (5.95 +/- 0.96), IPF (4.75 +/- 1.37) and hTB (5.97 +/- 1.05) groups. ET-1ur was significantly higher in S (189.50 +/- 60.57) than in HC (69.00 +/- 10.76), IPF (62.17 +/- 19.07) and hTB (82.00 +/- 24.97). After prednisone, ET-1ur in the S group decreased significantly (189.50 +/- 60.57 to 94.00 +/- 13.60), and the decrease paralleled the improved clinical status. In S patients, ET-1ur was not significantly correlated to the degree of respiratory impairment, but it was significantly correlated to the intensity of lymphocytic alveolitis (r = 0.80).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M Sofia; M Mormile; S Faraone; M Alifano; P Carratù; L Carratù |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Sarcoidosis Volume: 12 ISSN: 0393-1447 ISO Abbreviation: Sarcoidosis Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1996-02-01 Completed Date: 1996-02-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8500778 Medline TA: Sarcoidosis Country: ITALY |
Other Details:
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Languages: eng Pagination: 118-23 Citation Subset: IM |
Affiliation:
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Clinica di Malattie dell'Apparato Respiratorio Università di Napoli, Federico II, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / urine Endothelins / urine* Female Humans Lung Diseases, Interstitial / drug therapy, urine* Male Middle Aged Prednisone / therapeutic use Sarcoidosis, Pulmonary / urine* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelins; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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