Document Detail

Endothelin-1 and endotoxemia.
MedLine Citation:
PMID:  7509968     Owner:  NLM     Status:  MEDLINE    
Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls). ET-1 levels in plasma were analyzed by RIA. In both portal and systemic blood a twofold increase in ET-1 levels was found after 1 h. This level remained significantly elevated for a further 3 h. This increase was concurrent with a drop in cardiac output, systemic vascular resistance, and blood pressure. In the portal circulation there was increased portal pressure and vascular resistance. There was no significant difference between the systemic and portal levels of ET-1.
U Myhre; J T Pettersen; C Risøe; K E Giercksky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  22 Suppl 8     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-04-04     Completed Date:  1994-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S291-4     Citation Subset:  IM    
Department of Surgery, Norwegian Radiumhospital, Montebello, Oslo.
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Endothelins / blood,  immunology,  metabolism*
Escherichia coli / metabolism
Hemodynamics / drug effects
Lipopolysaccharides / toxicity*
Portal Vein / physiology
Vascular Resistance / drug effects
Reg. No./Substance:
0/Endothelins; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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