| Endothelin-1 and brain natriuretic peptide plasma levels decrease after aortic surgery. | |
| | |
MedLine Citation:
|
PMID: 21214096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM OF THE STUDY: Endothelin-1 (ET-1) and B-type natriuretic peptide (BNP) have been reported to be involved in numerous cardiovascular diseases. The study aim was to monitor the circulating plasma levels of these peptides in patients affected by aortic disease, and to identify any changes in such levels after surgical treatment. METHODS: A total of 81 patients (52 males, 29 females; mean age 64 +/- 11 years) with aortic disease underwent surgery. The conditions included aortic valve stenosis (n=36), aortic valve regurgitation (n=11), ascending aortic aneurysm (n=6), and combined ascending aortic aneurysm and valvulopathy (n=28). Circulating plasma levels of ET-1 and BNP were measured in all patients before and at 12 months after surgery. RESULTS: Compared to the preoperative situation, significant decreases were found postoperatively in plasma levels of ET-1 (4.2 +/- 0.1 versus 3.1 +/- 0.1 pM; p < 0.001) and BNP (0.071 versus 0.017 ng/ml; p < 0.001), combined with an increased cardiac function and decreased ventricular dimensions. The preoperative levels of both peptides were similar in all patient groups, and were decreased to a similar extent regardless of the diagnosis. Basal levels of ET-1 were higher in the trileaflet aortic valve compared to the bicuspid valve (4.0 +/- 0.1 versus 3.6 +/- 0.1 pM; p = 0.04). CONCLUSION: Circulating plasma levels of ET-1 and BNP were decreased after surgery for aortic valve disease. The decrease was unrelated to the presence of ascending aortic aneurysm, and most likely represents a response to cardiac remodeling and the improved functional status of the patients. |
| | |
Authors:
|
Giuseppe M Raffa; Veronica Jackson; Jan Liska; Maria J Eriksson; Kenneth Caidahl; Per Eriksson; Anders Franco-Cereceda |
Related Documents
:
|
2950986 - Elective oro-tracheal intubation to diagnose sleep apnea syndrome in children with down... 7283516 - Aortopulmonary septal defect: hemodynamics, angiography, and operation. 4083536 - Tetralogy of fallot produced in chick embryos by mechanical interference with cardiogen... 152056 - Apex sector echocardiography in evaluation of the right atrium in patients with mitral ... 20051406 - Hyponatremia in pulmonary tb: evidence of ectopic antidiuretic hormone production. 18442526 - Right ventricular reduction as an adjunct procedure in tricuspid valve repair. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of heart valve disease Volume: 19 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
|
Languages: eng Pagination: 724-30 Citation Subset: IM |
Affiliation:
|
Department of Cardiac Surgery, IRCCS Istituto Clinico Humanitas, Rozzano (MI), Italy. giuseppe.raffa78@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Aortic Aneurysm / blood, physiopathology, surgery* Aortic Valve Insufficiency / blood, physiopathology, surgery* Aortic Valve Stenosis / blood, physiopathology, surgery* Biological Markers / blood Blood Vessel Prosthesis Implantation* Down-Regulation Endothelin-1 / blood* Female Heart Valve Prosthesis Implantation* Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Prospective Studies Recovery of Function Stroke Volume Sweden Time Factors Treatment Outcome Ventricular Function, Left Ventricular Remodeling |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Endothelin-1; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of serum troponin I and plasma lactate concentrations in arrested versus beating-heart ao...
Next Document: Predictors for late insufficiency of the neo-aortic valve after the switch procedure.