| Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation. | |
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MedLine Citation:
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PMID: 19467500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A considerable rate of atrial fibrillation (AF) recurrence is one of the major limitations of pulmonary vein isolation (PVI). Although endothelin-1 (ET-1) is involved in atrial remodeling, it is unknown whether plasma ET-1 level before PVI can be used as a predictive factor for AF recurrence. OBJECTIVE: The goal of this study was to clarify whether the plasma ET-1 level, before PVI, can be used as a predictive factor for AF recurrence after PVI. METHODS: Fifty-one patients without structural heart disease who underwent PVI for symptomatic and drug-refractory paroxysmal/persistent AF were included in the study. Neurohumoral factors were measured, and transthoracic echocardiography was performed before and 6 months after each PVI. Mean left atrial (LA) pressure and arterial blood pressure (BP) were evaluated just before PVI. AF recurrence was detected by 12-lead electrocardiogram (ECG), Holter ECG, and event ECG monitor recordings, 3 to 6 months after PVI. RESULTS: Among plasma levels of ET-1, atrial and brain natriuretic peptides, renin, angiotensin II, and aldosterone before PVI, only ET-1 was significantly higher in the recurrence group compared with the nonrecurrence group (2.15 +/- 0.51 vs. 1.65 +/- 0.35 pg/ml, P < .001). Both mean LA pressure and diastolic BP in the recurrence group were significantly higher than in the nonrecurrence group (mean LA pressure, 10 +/- 3 vs. 8 +/- 3 mm Hg, P < .01; diastolic BP, 82 +/- 11 vs. 71 +/- 12 mm Hg, P < .01). The plasma ET-1 level and mean LA pressure were correlative. Multiple logistic regression analyses showed that higher levels of plasma ET-1 and diastolic BP were significant prognostic predictors of AF recurrence 3 to 6 months after PVI (P < .01 and P < .05, respectively). CONCLUSION: Our findings suggest that the plasma ET-1 level before PVI could be a crucial predictor of AF recurrence 3 to 6 months after PVI. |
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Authors:
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Yuko Nakazawa; Takashi Ashihara; Takayoshi Tsutamoto; Makoto Ito; Minoru Horie |
Publication Detail:
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Type: Journal Article Date: 2009-02-24 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 6 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-26 Completed Date: 2009-10-08 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 725-30 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular and Respiratory Medicine, Heart Rhythm Center, Shiga University of Medical Science, Otsu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Fibrillation / blood*, therapy* Biological Markers / blood Catheter Ablation Endothelin-1 / blood* Female Humans Male Middle Aged Predictive Value of Tests Pulmonary Veins Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelin-1 |
| Comments/Corrections | |
Comment In:
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Heart Rhythm. 2009 Jun;6(6):731-2
[PMID:
19467501
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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