Document Detail

[Endothelin 1 and angiotensin II in preeeclampsia].
MedLine Citation:
PMID:  17569300     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: It is generally thought that development of hypertension in preeclampsia (PE) is due to generalized endothelial dysfunction and/or results from an imbalance in the production and/or action of vasoactive factors, resulting in higher cytosolic Ca2+ concentration which in turn leads to vasoconstriction and decreased blood pressure perfusion in organs, including the fetoplacental unit. Among vasoactive factors involved in blood pressure regulation, endothelin 1 (ET-1) and angiotensin II (Ang II) regulate cytosolic Ca2+ concentrations and therefore are considered in this review. PE is associated with higher circulating and placental ET-1 levels, observation that explains, at least in part, vasoconstriction and oxidative stress. Higher and lower Ang II sensitivity seen in PE and normal pregnancy, respectively, could not be explained by changes in renin-angiotensin system components, including Ang II receptors (AT1). During normal pregnancy, AT1 receptors are found as monomers and are inactivated by reactive oxygen species (ROS) leading to lower Ang II sensitivity. In contrast, PE is associated with increased AT1/bradykinin receptors (B2) heterodimers which are resistant to inactivation by ROS, maintaining increased AT1-receptor stimulated signaling in PE. In addition, AT-1 agonistic antibodies (AT1-AA) obtained from PE women increases intracellular Ca2+, NADPH oxidase components and ROS, effects not observed with normal pregnancy AT1-AA.
CONCLUSION: High ET-1 levels, the presence of AT1/B2 receptor heterodimers and increased AT1-AA are involved, at least in part, in the hypertensive and oxidative stress states in PE.
Ana Carolina Ariza; Norma A Bobadilla; Ali Halhali
Publication Detail:
Type:  English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición     Volume:  59     ISSN:  0034-8376     ISO Abbreviation:  Rev. Invest. Clin.     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-09     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9421552     Medline TA:  Rev Invest Clin     Country:  Mexico    
Other Details:
Languages:  spa     Pagination:  48-56     Citation Subset:  IM    
Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán e Instituto de Investigaciones Biomédicas, UNAM, Tlalpan, México.
Vernacular Title:
Acciones de endotelina 1 y angiotensina II en embarazos complicados con preeclampsia.
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MeSH Terms
Angiotensin II / physiology*
Autoantibodies / immunology
Blood Pressure / drug effects,  physiology
Calcium Signaling
Endothelin-1 / biosynthesis,  physiology*
Maternal-Fetal Exchange
Models, Biological
Nitric Oxide / physiology
Oxidative Stress
Pre-Eclampsia / metabolism*,  physiopathology
Protein Interaction Mapping
Reactive Oxygen Species
Receptor, Angiotensin, Type 1 / chemistry,  immunology,  physiology*
Receptor, Bradykinin B2 / chemistry,  physiology*
Receptors, Endothelin / antagonists & inhibitors,  physiology
Renin-Angiotensin System / physiology
Signal Transduction / physiology
Reg. No./Substance:
0/Autoantibodies; 0/Endothelin-1; 0/Reactive Oxygen Species; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Bradykinin B2; 0/Receptors, Endothelin; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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