Document Detail

Endothelin-1 and U46619 potentiate selectively the venous responses to nerve stimulation within the perfused superior mesenteric vascular bed of the rat.
MedLine Citation:
PMID:  2241966     Owner:  NLM     Status:  MEDLINE    
The effects were examined of endothelin-1 and U46619 on the responses to perivascular nerve stimulation of the simultaneously perfused arterial and venous vessels of the superior mesenteric arterial bed of the rat. Stimulation of the nerves at 4-16 Hz for 30 s caused frequency dependent constrictions of both the arterial and venous vessels similar to those produced by bolus doses of exogenous noradrenaline (0.1-10 nmol). Infusion of either endothelin-1 (0.1 nM) or U46619 (1-3 nM) caused small (less than or equal to 5 mmHg) increases in arterial and venous perfusion pressures and selectively potentiated the venous, but not arterial, responses to nerve stimulation. Conversely, endothelin-1 and U46619 potentiated the responses of both the arterial and venous vessels to exogenous noradrenaline. Thus, as reported previously for the arterial vessels of the rat mesentery, the isolated venous vessels constrict to perivascular nerve stimulation in a frequency dependent manner. In addition, endothelin-1 and U46619 potentiate selectively the effects of nerve stimulation on the veins.
T D Warner; P D'Orleans-Juste; J R Vane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  172     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-12-05     Completed Date:  1990-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  745-50     Citation Subset:  IM    
William Harvey Research Institute, Medical College of St. Bartholomew's Hospital, London.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Electric Stimulation
Endothelins / pharmacology*
Guanethidine / pharmacology
Mesenteric Arteries / drug effects,  innervation,  physiology*
Mesenteric Veins / injuries,  innervation,  physiology*
Muscle, Smooth, Vascular / drug effects,  innervation,  physiology
Norepinephrine / pharmacology
Prostaglandin Endoperoxides, Synthetic / pharmacology
Rats, Inbred Strains
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Endothelins; 0/Prostaglandin Endoperoxides, Synthetic; 51-41-2/Norepinephrine; 55-65-2/Guanethidine; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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