Document Detail


Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: implications for airway remodeling in asthma.
MedLine Citation:
PMID:  14736087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The respiratory epithelium is a protective barrier that also functions as an interactive metabolically active component of the lung. The healing and repair of the epithelium involves initial migration of epithelial cells, and subsequent proliferation. The purpose of our study was to assess the effect of inflammatory mediators, in particular endothelin-1 (ET-1), on bronchial epithelial cell proliferation and migration. Under the conditions studied, ET-1 slows proliferation of human bronchial epithelial cells, compared to control (p < 0.01). The presence of ET-1 results in slower migration of epithelial cells compared to control (p < 0.04). Based on these in vitro findings, ET-1 could potentially lead to inhibition of repair of the lung epithelium and enhanced remodeling.
Authors:
A Dosanjh; B Zuraw
Related Documents :
3569657 - Collagen synthesis by long-lived mrna in embryonic chicken lens.
11981837 - Distinct expression of cyclooxygenase-1 and -2 in the human thymus.
2099677 - Multinucleate epithelial cells in the ductuli efferentes of human epididymis.
21277827 - Electrically modulated attachment and detachment of animal cells cultured on an optical...
23597197 - Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-...
17367397 - Basal expression rate of comk sets a 'switching-window' into the k-state of bacillus su...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  40     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-22     Completed Date:  2004-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  883-6     Citation Subset:  IM    
Affiliation:
Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. dosamr@scripps.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Asthma / physiopathology*
Bronchi / cytology,  physiopathology*
Cell Division / physiology
Cell Line
Cell Movement / physiology
Endothelin-1 / physiology*
Epithelial Cells / physiology*
Humans
Respiratory Mucosa / physiopathology
Chemical
Reg. No./Substance:
0/Endothelin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patients' expectations of asthma treatment.
Next Document:  Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD.