Document Detail

Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: implications for airway remodeling in asthma.
MedLine Citation:
PMID:  14736087     Owner:  NLM     Status:  MEDLINE    
The respiratory epithelium is a protective barrier that also functions as an interactive metabolically active component of the lung. The healing and repair of the epithelium involves initial migration of epithelial cells, and subsequent proliferation. The purpose of our study was to assess the effect of inflammatory mediators, in particular endothelin-1 (ET-1), on bronchial epithelial cell proliferation and migration. Under the conditions studied, ET-1 slows proliferation of human bronchial epithelial cells, compared to control (p < 0.01). The presence of ET-1 results in slower migration of epithelial cells compared to control (p < 0.04). Based on these in vitro findings, ET-1 could potentially lead to inhibition of repair of the lung epithelium and enhanced remodeling.
A Dosanjh; B Zuraw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  40     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-22     Completed Date:  2004-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  883-6     Citation Subset:  IM    
Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
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MeSH Terms
Asthma / physiopathology*
Bronchi / cytology,  physiopathology*
Cell Division / physiology
Cell Line
Cell Movement / physiology
Endothelin-1 / physiology*
Epithelial Cells / physiology*
Respiratory Mucosa / physiopathology
Reg. No./Substance:

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