Document Detail


Endothelial progenitor cell transplantation decreases lymphangiogenesis and adverse myocardial remodeling in a mouse model of acute myocardial infarction.
MedLine Citation:
PMID:  21694495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac lymphatic system in the remodeling after acute myocardial infarction (AMI) has been overlooked. We wanted to investigate the role of bone marrow-derived endothelial progenitor cells (EPCs) and their contribution to lymphatic distribution in myocardial remodeling after AMI. Mouse (C57bl/6J) MI models were created by ligation of the left anterior descending coronary artery and were treated with phosphate buffered saline (PBS) or EPCs. Real-time RT-PCR with 2- to 4-week myocardial tissue samples revealed that lymphangiogenetic factors such as vascular endothelial growth factor (VEGF)-C (8.5 fold, P < 0.05), VEGF-D (6.1 fold, P < 0.05), Lyve-1 (15 fold, P < 0.05), and Prox-1 (11 fold, P < 0.05) were expressed at significantly higher levels in the PBS group than the EPC group. The PBS group also showed a significantly higher density of lymphatic vessels in the peri-infarction area. Echocardiography showed that from 2 weeks after the treatment, left ventricle (LV) dimensions at both systole and diastole were significantly smaller in the EPC group than in the PBS group (P < 0.01) and LV fractional shortening was higher in the EPC group accordingly (P < 0.01). Lymphangiogenic markers increased in a mouse MI model. EPC transplantation decreased lymphangiogenesis and adverse ventricular remodeling after AMI. These novel findings suggest that new lymphatic vessels may be formed in severely damaged myocardium, and may be involved in adverse myocardial remodeling after AMI.
Authors:
Jae-Hyeong Park; Jung Yeon Yoon; Seon Mi Ko; Seon Ah Jin; Jun Hyung Kim; Chung-Hyun Cho; Jin-Man Kim; Jae-Hwan Lee; Si Wan Choi; In-Whan Seong; Jin Ok Jeong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  43     ISSN:  2092-6413     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-26     Completed Date:  2012-01-30     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  479-85     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Chungnam National University, Daejeon 301-721, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transplantation
Endothelial Cells / cytology*
Homeodomain Proteins / genetics,  metabolism
Immunohistochemistry
Lymphangiogenesis / genetics,  physiology*
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myocardial Infarction / metabolism,  physiopathology,  therapy*
Real-Time Polymerase Chain Reaction
Stem Cell Transplantation*
Tumor Suppressor Proteins / genetics,  metabolism
Vascular Endothelial Growth Factor A / genetics,  metabolism
Vascular Endothelial Growth Factor D / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Homeodomain Proteins; 0/Tumor Suppressor Proteins; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factor D; 0/prospero-related homeobox 1 protein
Comments/Corrections

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