| Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women. | |
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MedLine Citation:
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PMID: 16260885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy. METHODS: One hundred and sixteen pregnant women with placental abruption and 113 healthy controls were genotyped for Glu298Asp polymorphism in the eNOS gene. Chi-square analysis was used to assess the differences in genotype and allele frequencies between the two groups. RESULTS: A statistically similar allelic distribution of eNOS Glu298Asp polymorphism was observed in the two groups, with the frequency of the variant G allele being 66.8% in the abruption group and 68.1% in the control group (OR 0.94, 95% CI: 0.64-1.39; p = 0.76). The genotype distribution of the eNOS polymorphism was also found to be statistically similar (p = 0.72). CONCLUSIONS: The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the eNOS gene does not contribute to placental abruption in this population. |
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Authors:
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Sari Toivonen; Leea Keski-Nisula; Eeva-Liisa Romppanen; Seppo Helisalmi; Kari Punnonen; Seppo Heinonen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 20 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2006-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 508-11 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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genetics* Adult Female Finland Genetic Predisposition to Disease / genetics Humans Nitric Oxide Synthase Type III / genetics* Polymorphism, Genetic Pregnancy Prospective Studies Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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