Document Detail


Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese.
MedLine Citation:
PMID:  20882485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)(FE) = 1.26, 95% confidence interval (CI) = 1.10-1.44; a vs b allele: OR(FE) = 1.23, 95%CI: 1.09-1.40). Four studies with sample sizes over 500 produced similar results. No evidence of publication bias was found. Also, no significant heterogeneity was observed among these studies. When we examined the G894T polymorphism, we found a marginally significant association for allele contrast and the recessive model when all the eligible studies were pooled together. However, there was no evidence for a significant association after the exclusion of two studies deviating from Hardy-Weinberg equilibrium in the control group. Heterogeneity among studies was observed. Results of cumulative and recursive cumulative meta-analysis indicated that more studies are needed to objectively determine the effects of these two polymorphisms.
Authors:
H G Wang; J L Wang; P Chang; F L Cao; X C Liu; Y B Ma; G X Zhai; H Q Gao
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Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  9     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1896-907     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, Qilu Hospital, Shandong University, Jinan, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asian Continental Ancestry Group / genetics
Female
Genetic Predisposition to Disease
Humans
Hypertension / genetics*
Male
Middle Aged
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Genetic / genetics*
Chemical
Reg. No./Substance:
EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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