Document Detail


Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow.
MedLine Citation:
PMID:  18300744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: In this study, we aimed to investigate the relationship between T-786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene and slow coronary flow (SCF). STUDY DESIGN: A total of 56 patients with SCF but otherwise normal coronary arteries (mean age 48+/-9 years) and 37 controls with normal coronary angiograms (mean age 50+/-12 years) were enrolled in the study. Screening for the eNOS T-786C polymorphism was performed by restriction fragment length polymorphism methodology. RESULTS: In normal coronary artery and SCF groups, TT genotype frequency was 23 (62.2%) versus 22 (39.3%), TC heterozygote genotype frequency was 11 (29.7%) versus 30 (53.6%), and CC homozygote genotype frequency was 3 (8.1%) versus 4 (7.1%), respectively (P=0.07). In dominant model statistical analysis, total CC and CT genotype frequency in control and study groups was found to be 14 (37.3%) versus 34 (60.7%), respectively (P=0.025). A positive correlation was found between the mean thrombolysis in myocardial infarction frame count and C allele in patients with SCF (r=0.21, P=0.043). CONCLUSION: We concluded that the T-786C polymorphism of eNOS gene might be a risk factor for the SCF.
Authors:
Zekeriya Nurkalem; Burak Tangurek; Ertugrul Zencirci; Ahmet T Alper; Huseyin Aksu; Betul Erer; Sevket Gorgulu; Figen Ciloglu; Mehmet Eren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  19     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Affiliation:
Siyami Ersek Cardiovascular and Thoracic Surgery Center, Training and Research Hospital, Istanbul, Turkey. zeknurkalem@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Coronary Angiography
Coronary Circulation*
Coronary Vessels / physiopathology*
Female
Genetic Predisposition to Disease
Hemorheology
Humans
Male
Middle Aged
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Single Nucleotide / genetics*
Chemical
Reg. No./Substance:
EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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