Document Detail


Endothelial nitric oxide synthase activation contributes to post-exercise hypotension in spontaneously hypertensive rats.
MedLine Citation:
PMID:  19306842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the role that endothelial nitric oxide synthase plays in post-exercise hypotension in spontaneously hypertensive rats. To accomplish this, rats were subjected to a single bout of dynamic exercise on a treadmill at 15 m/min for 20 min. L-nitroarginine methyl ester (L-NAME, 40 mg/kg, i.p.) significantly inhibited post-exercise hypotension (25+/-11 and 5+/-3 mm Hg, respectively; P<0.05). In addition, the superoxide anion generation was decreased, while the plasma nitrite production and serine phosphorylation of endothelial nitric oxide synthase were significantly elevated in spontaneously hypertensive rats at 30 min after the termination of exercise. Taken together, these data demonstrate that the increased phosphorylation of endothelial nitric oxide synthase plays a crucial role in the reduction of arterial pressure following a single bout of dynamic exercise in spontaneously hypertensive rats.
Authors:
Sang Ki Lee; Cuk Seong Kim; Hyo Shin Kim; Eun Jung Cho; Hee Kyoung Joo; Ji Young Lee; Eun Ji Lee; Jin Bong Park; Byeong Hwa Jeon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-21
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  382     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  711-4     Citation Subset:  IM    
Affiliation:
Infection Signaling Network Research Center, Research Institutes of Biomedical Science, Department of Physiology, College of Medicine, Chungnam National University, Jung-Gu, Daejeon, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Activation
Enzyme Inhibitors / pharmacology
Hypotension / enzymology*
Male
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase Type III / antagonists & inhibitors,  metabolism*
Phosphorylation
Physical Conditioning, Animal
Rats
Rats, Inbred SHR
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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