Document Detail

Endothelial nitric oxide synthase Glu(298)-->Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample.
MedLine Citation:
PMID:  16060860     Owner:  NLM     Status:  MEDLINE    
The Glu(298)-->Asp (E298D; 894G-->T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease. In the present study, we investigated the association of Glu(298)-->Asp with atherosclerotic plaques in different carotid vessel segments and with carotid IMT (intima-media thickness). The Glu(298)-->Asp eNOS polymorphism was determined by 5'-exonuclease assay among 2448 participants of the SHIP (Study of Health in Pomerania). Mean and maximum common carotid IMT, as well as carotid atherosclerosis, were measured by high-resolution ultrasound. The Asp/Asp(298) genotype was associated with an increased risk of atherosclerotic plaques at the level of the common carotid arteries [multivariate odds ratio, 1.57 and 95% CI (confidence interval), 1.05-2.34; P=0.025], but not in the carotid bifurcations or internal or external carotid arteries. Glu(298)-->Asp genotype was not associated with carotid IMT in the whole sample. However, the Asp/Asp(298) genotype was independently associated with both higher mean [adjusted increase by 0.046 mm (95% CI, 0.013-0.078); P=0.006] and maximum carotid IMT [0.137 mm (95% CI, 0.064-0.209); P<0.001] in the low-risk group of subjects without carotid atherosclerosis. In conclusion, the Asp/Asp(298) genotype is associated with atherosclerosis in the common carotid arteries and, in a low-risk group, also with carotid IMT. This suggests that the association of the Glu(298)-->Asp genotype with atherosclerosis in the carotid arteries is site-specific and is modified by overall cardiovascular risk.
Birger Wolff; Claudia Braun; Christina Schlüter; Hans J Grabe; Katrin Popowski; Henry Völzke; Jan Lüdemann; Ulrich John; Ingolf Cascorbi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  109     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2006-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
Klinik für Innere Medizin B, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.
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MeSH Terms
Atherosclerosis / genetics*,  pathology,  ultrasonography
Cardiovascular Diseases / etiology
Carotid Artery Diseases / genetics*,  pathology,  ultrasonography
Carotid Artery, Common / pathology,  ultrasonography
Cross-Sectional Studies
Middle Aged
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Genetic*
Risk Factors
Tunica Intima / pathology
Tunica Media / pathology
Reg. No./Substance:
EC protein, human; EC Oxide Synthase Type III

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