| Endothelial haemostatic factors may be associated with mortality in patients on long-term anticoagulant treatment. | |
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MedLine Citation:
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PMID: 8584993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to test if long-term mortality could be predicted by endothelial derived haemostatic variables in a population with high morbidity due to thromboembolic disease. Plasma samples were drawn from 212 out-patients treated with oral anticoagulants, at the beginning of the study, and analyzed for mass concentration of tissue plasminogen activator (tPA) and its inhibitor (PAI-1), and von Willebrand factor. In the course of 3.8-year follow-up 45 patients died, including 38 vascular deaths. We found that all-cause mortality was significantly associated with increased levels of vWF and tPA. For vascular mortality there was a significant association with all three haemostatic variables (tPA, PAI-1, vWF). For vWF there was a 3-fold increase in total and vascular mortality in the highest quartile compared to the lowest quartile. There were 27 vascular deaths in the group of patients with a tPA-value above the median compared to 11 in those with a tPA below the median. In multivariate Cox regression analysis (including: age, sex, smoking habits, body mass index, diabetes mellitus, hypertension, tPA, PAI-1, and vWF), vWF and smoking were independently significantly associated with all-cause mortality, and tPA and age with vascular mortality. Endothelial derived haemostatic variables are predictors of total and vascular mortality in patients treated with oral anticoagulants. |
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Authors:
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M Brännström; J H Jansson; K Boman; T K Nilsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 74 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-03-21 Completed Date: 1996-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 612-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Skellefteå Hospital, Umeå, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Cardiovascular Diseases / etiology, mortality*, physiopathology Cause of Death Comorbidity Diabetes Mellitus / epidemiology Endothelium, Vascular / physiopathology* Follow-Up Studies Hemostasis* Humans Hypertension / epidemiology Obesity / epidemiology Plasminogen Activator Inhibitor 1 / analysis* Proportional Hazards Models Risk Factors Smoking / epidemiology Thromboembolism / drug therapy* Tissue Plasminogen Activator / analysis* von Willebrand Factor / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Plasminogen Activator Inhibitor 1; 0/von Willebrand Factor; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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