Document Detail

Endothelial haemostatic factors may be associated with mortality in patients on long-term anticoagulant treatment.
MedLine Citation:
PMID:  8584993     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to test if long-term mortality could be predicted by endothelial derived haemostatic variables in a population with high morbidity due to thromboembolic disease. Plasma samples were drawn from 212 out-patients treated with oral anticoagulants, at the beginning of the study, and analyzed for mass concentration of tissue plasminogen activator (tPA) and its inhibitor (PAI-1), and von Willebrand factor. In the course of 3.8-year follow-up 45 patients died, including 38 vascular deaths. We found that all-cause mortality was significantly associated with increased levels of vWF and tPA. For vascular mortality there was a significant association with all three haemostatic variables (tPA, PAI-1, vWF). For vWF there was a 3-fold increase in total and vascular mortality in the highest quartile compared to the lowest quartile. There were 27 vascular deaths in the group of patients with a tPA-value above the median compared to 11 in those with a tPA below the median. In multivariate Cox regression analysis (including: age, sex, smoking habits, body mass index, diabetes mellitus, hypertension, tPA, PAI-1, and vWF), vWF and smoking were independently significantly associated with all-cause mortality, and tPA and age with vascular mortality. Endothelial derived haemostatic variables are predictors of total and vascular mortality in patients treated with oral anticoagulants.
M Brännström; J H Jansson; K Boman; T K Nilsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  74     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  612-5     Citation Subset:  IM    
Department of Medicine, Skellefteå Hospital, Umeå, Sweden.
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MeSH Terms
Anticoagulants / therapeutic use*
Cardiovascular Diseases / etiology,  mortality*,  physiopathology
Cause of Death
Diabetes Mellitus / epidemiology
Endothelium, Vascular / physiopathology*
Follow-Up Studies
Hypertension / epidemiology
Obesity / epidemiology
Plasminogen Activator Inhibitor 1 / analysis*
Proportional Hazards Models
Risk Factors
Smoking / epidemiology
Thromboembolism / drug therapy*
Tissue Plasminogen Activator / analysis*
von Willebrand Factor / analysis*
Reg. No./Substance:
0/Anticoagulants; 0/Plasminogen Activator Inhibitor 1; 0/von Willebrand Factor; EC Plasminogen Activator

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