Document Detail


Endothelial function progressively deteriorates during normal pregnancy.
MedLine Citation:
PMID:  23725078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels.
METHODS: Endothelial function was evaluated by reactive hyperemia index (RHI) using Endo-PAT2000 and plasma sFlt-1 levels were measured simultaneously by ELISA.
RESULTS: RHI gradually deteriorated with increasing gestational age. Plasma sFlt-1 levels exhibited a gradual increase at late pregnancy and were inversely correlated with RHI.
CONCLUSION: Maternal endothelial function gradually deteriorates with increasing gestational age and there is an inverse correlation between endothelial function and plasma sFlt-1 levels in normal pregnancy.
Authors:
Kohei Fujita; Keiji Tatsumi; Eiji Kondoh; Yoshitsugu Chigusa; Haruta Mogami; Masatoshi Fujita; Ikuo Konishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  32     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-06-03     Completed Date:  2014-04-22     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Endothelium, Vascular / physiology*
Female
Humans
Hyperemia
Manometry
Middle Aged
Pre-Eclampsia / blood,  physiopathology
Pregnancy / physiology*
Prospective Studies
Vascular Endothelial Growth Factor Receptor-1 / blood
Young Adult
Chemical
Reg. No./Substance:
EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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