Document Detail

Endothelial function progressively deteriorates during normal pregnancy.
MedLine Citation:
PMID:  23725078     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels.
METHODS: Endothelial function was evaluated by reactive hyperemia index (RHI) using Endo-PAT2000 and plasma sFlt-1 levels were measured simultaneously by ELISA.
RESULTS: RHI gradually deteriorated with increasing gestational age. Plasma sFlt-1 levels exhibited a gradual increase at late pregnancy and were inversely correlated with RHI.
CONCLUSION: Maternal endothelial function gradually deteriorates with increasing gestational age and there is an inverse correlation between endothelial function and plasma sFlt-1 levels in normal pregnancy.
Kohei Fujita; Keiji Tatsumi; Eiji Kondoh; Yoshitsugu Chigusa; Haruta Mogami; Masatoshi Fujita; Ikuo Konishi
Related Documents :
2483128 - Insulin-like growth factor-i expression during early conceptus development in the pig.
23725078 - Endothelial function progressively deteriorates during normal pregnancy.
813278 - Prostaglandin synthesis in decidual tissue of the rate uterus.
8229938 - Biology of ovarian cycles, pregnancy and pseudopregnancy in the domestic cat.
9394168 - Fetal acidemia in the absence of fluid observed at amniotomy.
8694798 - Hormonal influences on beta-lactoglobulin transgene expression inferred from chromatin ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  32     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-06-03     Completed Date:  2014-04-22     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Endothelium, Vascular / physiology*
Middle Aged
Pre-Eclampsia / blood,  physiopathology
Pregnancy / physiology*
Prospective Studies
Vascular Endothelial Growth Factor Receptor-1 / blood
Young Adult
Reg. No./Substance:
EC Endothelial Growth Factor Receptor-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Increase of placental sensitivity to melatonin and the alteration to its local synthesis in hyperten...
Next Document:  Predictive value of 3+ spot urinary protein value measured by dipstick in hypertensive pregnant pati...