Document Detail

Endothelial function in offspring of Type 1 diabetic patients with and without diabetic nephropathy.
MedLine Citation:
PMID:  10220203     Owner:  NLM     Status:  MEDLINE    
AIMS: Familial aggregation of diabetes and nephropathy has been observed in several populations. Various interpretations have included underlying genetic mechanisms possibly mediated by a predisposition to hypertension. Endothelial dysfunction is now recognized as central to these conditions and offers a unifying mechanism to explain the disease aggregation. To test this hypothesis, we have examined endothelial function in healthy subjects at differing risks for diabetic nephropathy. METHODS: Endothelial function was assessed in 12 healthy offspring (nine male (M)/three female (F); age 25.8+/-1.2 years, mean +/- SEM) of parents with Type 1 diabetes mellitus (DM) and end-stage renal disease compared with 12 control offspring (9 M/3 F; age 26.3+/-1.3 years) of parents with long duration (>20 years) Type 1 DM but without evidence of nephropathy. Forearm blood flow responses to brachial artery infusion of acetylcholine (endothelium-dependent), sodium nitroprusside (endothelium-independent), noradrenaline and the competitive inhibitor of basal nitric oxide release N(G)-monomethyl-L-arginine were assessed using venous occlusion plethysmography. RESULTS: There were no significant differences between the groups in von Willebrand factor, fasting plasma glucose (4.2+/-0.1 vs. 4.0+/-0.2 mmol/l) or in 24-h ambulatory blood pressure. Similarly, the groups did not differ in vasodilation to acetylcholine (P = 0.75) and sodium nitroprusside (P = 0.79) or in vasoconstriction to noradrenaline (P = 0.45) and N(G)-monomethyl-L-arginine (P = 0.30). CONCLUSION: These data do not support a role for endothelial dysfunction in the familial aggregation of diabetic nephropathy.
A S McAllister; A B Atkinson; G D Johnston; D R McCance
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  16     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  298-303     Citation Subset:  IM    
Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, UK.
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MeSH Terms
Chronic Disease
Diabetes Mellitus, Type 1 / complications,  physiopathology*
Diabetic Nephropathies / etiology,  physiopathology*
Endothelium, Vascular / physiopathology*
Family Health*
Forearm / blood supply
Reference Values
Regional Blood Flow
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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