Document Detail

Endothelial function and cardiovascular risk in patients with Idiopathic Sudden Sensorineural Hearing Loss.
MedLine Citation:
PMID:  23102449     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate cardiovascular risk factors and pre-clinical atherosclerosis in subjects affected by Idiopathic Sudden Sensorineural Hearing Loss (ISSHL). METHODS: In this study, 29 ISSHL patients and 29 healthy controls were evaluated. All of the patients underwent a complete audiovestibular and clinical evaluation. Carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD) of the brachial artery were assessed as early markers of atherosclerosis. RESULTS: Our results showed that FMD was significantly lower in the ISSHL patients than in the controls (5.6 ± 1.6% vs. 7.7 ± 3.7%, p < 0.01). Moreover, the total cholesterol and low density lipoprotein cholesterol were significantly higher in the ISSHL patients than in the controls (p < 0.05). The two groups did not differ with regards to C-IMT and other cardiovascular risk factors. Vestibular involvement was shown to be associated with lower FMD values (4.1 ± 1.7% vs. 5.8 ± 1.5%, p < 0.05). No relationship was found between C-IMT and vestibular involvement. Finally, multiple logistic regression highlighted the finding that only FMD values seemed to predispose individuals to developing ISSHL (p = 0.03, OR: 1.4). CONCLUSIONS: ISSHL seemed to be associated with vascular endothelial dysfunction and an increased cardiovascular risk, which supports the hypothesis of a vascular aetiology for this disease.
Marco Matteo Ciccone; Francesca Cortese; Mariangela Pinto; Concetta Di Teo; Fara Fornarelli; Michele Gesualdo; Antonia Mezzina; Evelina Sabatelli; Pietro Scicchitano; Nicola Quaranta
Related Documents :
23717589 - Short-term clinical implications of the accessory left hepatic artery in patients under...
24203069 - Effects of treatment with metformin on tsh levels: a meta-analysis of literature studies.
25130949 - The sympathetic skin response located in the penis as a predictor of the response to se...
23796379 - Brachioradial pruritus: mayo clinic experience over the past decade.
24657679 - Evidence for involvement of the cd40/cd40l system in post-stroke epilepsy.
23525079 - Prognostic significance of multidetector ct in normotensive patients with pulmonary emb...
10753419 - Prediction of vertigo recurrences in meniere's disease by the head-shaking test.
18227989 - Extensive cortical inflammation is associated with epilepsy in multiple sclerosis.
22432969 - Transient elastography and simple blood markers in diagnosis of oesophageal varices for...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physical activity modifies the associations between genetic variants and hypertension in the Chinese...
Next Document:  A high CHA(2)DS(2)-VASc score is associated with a high risk for critical limb ischemia in periphera...