Document Detail


Endothelial dysfunction and sympathetic nervous system activation in young patients with essential arterial hypertension and without hypercholesterolaemia.
MedLine Citation:
PMID:  21125975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the study was to evaluate whether measurements of hs-C-reactive protein (hs-CRP), endothelin-1 (ET-1), epinephrine (E) and norepinephrine (NE) would provide useful information for the assessment of endothelial dysfunction and sympathetic nervous system activation in a selected group of young, properly treated patients with essential arterial hypertension (HTN) and without hypercholesterolaemia.
METHODS AND RESULTS: Serum hs-CRP and ET-1 as well as plasma epinephrine and norepinephrine concentrations were measured in 134 subjects (62 patients with diagnosed HTN and 72 healthy subjects from a reference group). In patients the concentrations of hs-CRP, ET-1 and NE were significantly higher, than in healthy subjects. The highest diagnostic sensitivity (87%; 95% CI 76.1-94.2) was found for serum hs-CRP; the highest diagnostic specificity (96%; 95% CI 88.3-99.1) and positive predictive value (89%) were found for ET-1 measurements. The analysis of logistic regression showed that the highest risk of HTN was found for the patients with high levels of ET-1, hs-CRP and NE, but not epinephrine.
CONCLUSIONS: These results indicate that measurements of hs-CRP, ET-1 and NE may be useful in the identification of endothelial dysfunction and sympathetic activation in young patients with properly controlled essential arterial hypertension and without hyperlipidaemia.
Authors:
Agnieszka M Kuklinska; Barbara Mroczko; Wlodzimierz J Musial; Robert Sawicki; Karol Kaminski; Monika Usowicz-Szarynska; Maciej Szmitkowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cardiologica     Volume:  65     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  535-40     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
C-Reactive Protein / analysis
Endothelin-1 / blood
Endothelium, Vascular / physiopathology*
Epinephrine / blood
Female
Humans
Hypertension / physiopathology*
Logistic Models
Male
Middle Aged
Norepinephrine / blood
Sensitivity and Specificity
Sympathetic Nervous System / physiopathology*
Chemical
Reg. No./Substance:
0/Endothelin-1; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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