| Endothelial dysfunction, measured by reactive hyperaemia using strain-gauge plethysmography, is an independent predictor of adverse outcome in heart failure. | |
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MedLine Citation:
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PMID: 20354033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: In congestive heart failure (CHF), arterial response is regulated by endothelial molecules. The aim of this study was to evaluate whether endothelial dysfunction (ED) was a predictor of outcome in a cohort of patients with heart failure. METHODS AND RESULTS: Endothelial function was assessed in 242 patients with CHF by forearm reactive hyperaemia measured with intermittent venous occlusion plethysmography using a mercury strain gauge. The main endpoints were: 'total events' (death, heart attack, angina, stroke, NYHA class IV, or hospitalization due to heart failure) analysed using Cox regression for repeated events and 'death'. Patients were followed-up for 5 years. Post-hyperaemia forearm blood flow (PHFABF) was an independent predictor of total events [P = 0.01; hazard ratio [Exp(B)] 0.665, standard error (SE) 0.182]. Risk stratification by basal forearm blood flow (BFABF) showed that patients with basal blood flow above the median (3.03 mL min(-1) 100 mL(-1)) benefited from an increase in PHFABF, whereas in patients with a BFABF below the median, the increase in PHFABF did not diminish the risk of events. There was no relation between variations in PHFABF and death. CONCLUSION: Post-hyperaemia forearm blood flow, as a measure of ED, is an independent predictor of major events in patients with CHF. A BFABF below the median is more predictive of an increased risk of complications. |
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Authors:
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José R de Berrazueta; Armando Guerra-Ruiz; María Teresa García-Unzueta; Gema Martín Toca; Rocío Sainz Laso; María Sáez de Adana; Miguel A Casanova Martín; Manuel Cobo; Javier Llorca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-30 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2011-06-02 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 477-83 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Research Unit IFIMAV, Cantabria University, Universitary Hospital Valdecilla, Santander, Spain. joseramon@berrazueta.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiography, Impedance Confidence Intervals Endothelium, Vascular / pathology* Female Forearm / blood supply* Health Status Indicators Heart Failure / complications, diagnosis*, drug therapy, mortality Hemodynamics Humans Hyperemia / diagnosis* Kaplan-Meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Statistics as Topic Treatment Outcome |
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