| Endothelial dysfunction, intima-media thickness, ankle-brachial pressure index, and pulse pressure in young post-myocardial infarction patients with various expressions of classical risk factors. | |
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MedLine Citation:
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PMID: 17653514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary risk assessment based on the presence of classical risk factors may be insufficient. Several markers of arterial function and morphology, such as endothelial dysfunction (ED), intima-media thickness (IMT), ankle-brachial pressure index (ABPI), and pulse pressure (PP) may be useful in coronary risk estimation. To investigate their usefulness, we compared them in young post-myocardial infarction (MI) patients with various expressions of classical risk factors. Young male patients (on average 44 years old) in the stable phase after MI were included in the study. Twenty patients had high and 21 patients low expression of risk factors, while 25 healthy age-matched males served as controls. Endothelial dysfunction (estimated by ultrasound measurement of the flow-mediated dilation [FMD] of the brachial artery), IMT (of common carotid arteries), ABPI, and PP were compared between both groups of patients and controls. Compared with the control group, endothelial function and IMT were significantly impaired in both groups of patients, whereas ABPI was significantly reduced only in high-risk patients, and PP was similar in patients and controls. In all subjects, the level of FMD was significantly negatively related to IMT (r = -0.38, P = 0.01). Our study showed that endothelial function and IMT (but not ABPI and PP) are impaired in young post-MI patients independently of presence or absence of classical risk factors. Thus, we conclude that in young patients ED and IMT better assess coronary disease than classical risk factors, and are probably better markers of coronary risk. |
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Authors:
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Barbara Erzen; Miso Sabovic; Miran Sebestjen; Pavel Poredos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-20 |
Journal Detail:
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Title: Heart and vessels Volume: 22 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2008-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: IM |
Affiliation:
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Department of Vascular Disease, University Medical Centre, Zaloska 2, 1000 Ljubljana, Slovenia. erzen_b@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Ankle / blood supply Blood Flow Velocity / physiology Blood Glucose / metabolism Blood Pressure / physiology* Brachial Artery / physiopathology Carotid Artery, Common / physiopathology, ultrasonography Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Angiography Endothelium, Vascular / physiopathology*, ultrasonography Humans Male Middle Aged Myocardial Infarction / etiology, physiopathology*, ultrasonography Nitroglycerin / diagnostic use Predictive Value of Tests Risk Factors Tibial Arteries / physiopathology Triglycerides / blood Tunica Intima / physiopathology*, ultrasonography Tunica Media / physiopathology*, ultrasonography Ultrasonography, Doppler Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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