Document Detail


Endothelial dysfunction in patients with polycythaemia vera.
MedLine Citation:
PMID:  11703335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with polycythaemia vera (PV) are at increased risk of developing arterial and venous thromboembolic complications. We investigated whether endothelium-dependent, flow-mediated vasodilatation (FMD) is impaired in PV patients without clinical evidence of artery disease as observed in patients with conventional cardiovascular risk factors. FMD and endothelium-independent, nitroglycerine-induced vasodilatation (NMD) were assessed using high-resolution ultrasound in the brachial artery of 20 patients with PV and 20 sex- and age-matched control subjects (CTL). FMD was markedly impaired in PV patients compared with CTL (7.6 +/- 2.9% versus 11.6 +/- 5.7%, P = 0.009) whereas NMD was similar in both study groups. The impairment of FMD was independently related to the presence of PV (r = -0.434, P = 0.009) and vessel size (r = -0.107, P = 0.038) but was not related to haematocrit values and platelet counts. The results demonstrate that PV is associated with endothelial dysfunction in the pre-clinical phase of arterial disease. However, the precise mechanisms by which PV leads to this altered vascular reactivity remain unclear.
Authors:
T Neunteufl; S Heher; T Stefenelli; I Pabinger; H Gisslinger
Related Documents :
20824765 - Left atrial appendage closure with amplatzer cardiac plug in atrial fibrillation: initi...
17545655 - Inducible supraventricular tachycardias in patients referred for catheter ablation of a...
3145585 - Clinical effect of bretschneider-htk and st. thomas cardioplegia on hemodynamic perform...
18973495 - High-resolution signal-averaged analysis of atrial electromagnetic characteristics in p...
15378185 - Evaluation of dose-volume histograms after prostate seed implantation. 4-year experience.
10651725 - Effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous le...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  115     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University of Vienna, Vienna, Austria. thomas.neunteufl@univie.ac.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brachial Artery / physiopathology,  ultrasonography
Case-Control Studies
Endothelium, Vascular / physiopathology*
Female
Humans
Male
Middle Aged
Nitroglycerin / diagnostic use
Polycythemia Vera / physiopathology*,  ultrasonography
Risk Factors
Vasodilation / physiology*
Vasodilator Agents / diagnostic use
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  beta-Spectrin S(ta) Bárbara: a novel frameshift mutation in hereditary spherocytosis associated wit...
Next Document:  Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria.