Document Detail

Endothelial dysfunction in patients with polycythaemia vera.
MedLine Citation:
PMID:  11703335     Owner:  NLM     Status:  MEDLINE    
Patients with polycythaemia vera (PV) are at increased risk of developing arterial and venous thromboembolic complications. We investigated whether endothelium-dependent, flow-mediated vasodilatation (FMD) is impaired in PV patients without clinical evidence of artery disease as observed in patients with conventional cardiovascular risk factors. FMD and endothelium-independent, nitroglycerine-induced vasodilatation (NMD) were assessed using high-resolution ultrasound in the brachial artery of 20 patients with PV and 20 sex- and age-matched control subjects (CTL). FMD was markedly impaired in PV patients compared with CTL (7.6 +/- 2.9% versus 11.6 +/- 5.7%, P = 0.009) whereas NMD was similar in both study groups. The impairment of FMD was independently related to the presence of PV (r = -0.434, P = 0.009) and vessel size (r = -0.107, P = 0.038) but was not related to haematocrit values and platelet counts. The results demonstrate that PV is associated with endothelial dysfunction in the pre-clinical phase of arterial disease. However, the precise mechanisms by which PV leads to this altered vascular reactivity remain unclear.
T Neunteufl; S Heher; T Stefenelli; I Pabinger; H Gisslinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  115     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  IM    
Department of Cardiology, University of Vienna, Vienna, Austria.
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MeSH Terms
Brachial Artery / physiopathology,  ultrasonography
Case-Control Studies
Endothelium, Vascular / physiopathology*
Middle Aged
Nitroglycerin / diagnostic use
Polycythemia Vera / physiopathology*,  ultrasonography
Risk Factors
Vasodilation / physiology*
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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