| Endothelial dysfunction in patients with polycythaemia vera. | |
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MedLine Citation:
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PMID: 11703335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with polycythaemia vera (PV) are at increased risk of developing arterial and venous thromboembolic complications. We investigated whether endothelium-dependent, flow-mediated vasodilatation (FMD) is impaired in PV patients without clinical evidence of artery disease as observed in patients with conventional cardiovascular risk factors. FMD and endothelium-independent, nitroglycerine-induced vasodilatation (NMD) were assessed using high-resolution ultrasound in the brachial artery of 20 patients with PV and 20 sex- and age-matched control subjects (CTL). FMD was markedly impaired in PV patients compared with CTL (7.6 +/- 2.9% versus 11.6 +/- 5.7%, P = 0.009) whereas NMD was similar in both study groups. The impairment of FMD was independently related to the presence of PV (r = -0.434, P = 0.009) and vessel size (r = -0.107, P = 0.038) but was not related to haematocrit values and platelet counts. The results demonstrate that PV is associated with endothelial dysfunction in the pre-clinical phase of arterial disease. However, the precise mechanisms by which PV leads to this altered vascular reactivity remain unclear. |
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Authors:
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T Neunteufl; S Heher; T Stefenelli; I Pabinger; H Gisslinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 115 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-12 Completed Date: 2001-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 354-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Vienna, Vienna, Austria. thomas.neunteufl@univie.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brachial Artery / physiopathology, ultrasonography Case-Control Studies Endothelium, Vascular / physiopathology* Female Humans Male Middle Aged Nitroglycerin / diagnostic use Polycythemia Vera / physiopathology*, ultrasonography Risk Factors Vasodilation / physiology* Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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