| Endothelial dysfunction in the nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 18928161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The nephrotic syndrome is associated with an increased risk ofatherosclerosis and endothelial dysfunction. Endothelial dysfunction was assessed and correlated with dyslipidemia and markers of inflammation in patients with nephrotic syndrome. 20 patients were divided into two groups: group A (10 patients with primary nephrotic syndrome) and group B, 10 controls. The endothelial function was assessed by means of flow mediated dilation on brachial artery, using B-mode ultrasonography. The values of flow mediated dilation were 4 +/- 1.49% (group A) and 11.95 +/- 0.24% (group B), p<0.01. There was a very strong inverse correlation between flow mediated dilation and LDL-cholesterol (r=-0.9650, p<0.001), total cholesterol (r=-0.9399, p<0.001), and fibrinogen (r=-0.7127, p<0.001), and a weak correlation with triglycerides (r=-0.2880. p<0.01), and positive correlation with respective HDL-cholesterol (r=0.4020, p<0.001). The most important factors involved in the endothelial dysfunction in the nephrotic syndrome are LDL-cholesterol, total cholesterol and fibrinogen and their treatment is necessary to prevent atherosclerosis in patients with nephrotic syndrome. |
| | |
Authors:
|
Alex Caraba; Ioan Romoşan |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Medicinski pregled Volume: 60 Suppl 2 ISSN: 0025-8105 ISO Abbreviation: Med. Pregl. Publication Date: 2007 |
Date Detail:
|
Created Date: 2008-10-20 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985249R Medline TA: Med Pregl Country: Serbia |
Other Details:
|
Languages: eng Pagination: 66-9 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Nephrology, University of Medicine and Pharmacy Victor Babeş Timişoara, Romania. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Flow Velocity Brachial Artery / ultrasonography Endothelium, Vascular / physiopathology* Female Fibrinogen / analysis Humans Lipids / blood Male Nephrotic Syndrome / metabolism, physiopathology* Vasodilation |
| Chemical | |
Reg. No./Substance:
|
0/Lipids; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of effects of the intravenous cyclophosphamide treatment of primary glomerulonephritis an...
Next Document: Neuropsychiatric lupus in patients with lupus glomerulonephritis.