Document Detail

Endothelial dysfunction, ADMA and insulin resistance in essential hypertension.
MedLine Citation:
PMID:  19168237     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial dysfunction and insulin resistance (IR) are associated with essential hypertension and other cardiovascular risk factors. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction in different setting of patients. However, at this moment no data are available about the role of ADMA and IR to induce endothelial dysfunction in an independent way or combined between them. In this study, we investigated, in 63 hypertensives and 21 normotensive healthy subjects, the relationship between ADMA and IR and their possible interaction on endothelial function. METHODS: ADMA plasma levels were measured by high-performance liquid chromatography, and IR by homeostasis model assessment (HOMA). Endothelial function was estimated by intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside at increasing doses. RESULTS: Hypertensive patients had significantly higher ADMA, insulin, HOMA and C-reactive protein (CRP) values than normotensive controls (P<0.0001). There were no significant differences in mean l-arginine/ADMA ratio between groups. ACh-stimulated forearm blood flow (FBF) was significantly reduced in hypertensive patients (P<0.0001). In hypertensive group, HOMA was the strongest determinant of FBF, accounting for the 45.5% of its variation. ADMA and gender were the independent determinants of HOMA, accounting for 12.3% and 8.3% of its variation, respectively. CONCLUSIONS: The association between ADMA and IR contributes to identify a possible novel mechanism by which ADMA promotes vascular damage, increasing individual cardiovascular risk in hypertensive patients. However, this hypothesis should be tested in a larger study group.
Francesco Perticone; Angela Sciacqua; Raffaele Maio; Maria Perticone; Giulia Galiano Leone; Rosamaria Bruni; Serena Di Cello; Alessandra Pascale; Giusy Talarico; Laura Greco; Francesco Andreozzi; Giorgio Sesti
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2009-01-24
Journal Detail:
Title:  International journal of cardiology     Volume:  142     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Italy.
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MeSH Terms
Acetylcholine / administration & dosage
Arginine / analogs & derivatives*,  blood
Case-Control Studies
Endothelium, Vascular / drug effects,  metabolism*,  physiopathology
Homeostasis / drug effects,  physiology
Hypertension / epidemiology,  metabolism*,  physiopathology
Insulin Resistance / physiology*
Middle Aged
Nitric Oxide Synthase Type III / metabolism
Nitroprusside / administration & dosage
Regional Blood Flow / drug effects,  physiology
Risk Factors
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 30315-93-6/N,N-dimethylarginine; 51-84-3/Acetylcholine; 74-79-3/Arginine; EC protein, human; EC Oxide Synthase Type III

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