Document Detail


Endothelial damage during myocardial preservation and storage.
MedLine Citation:
PMID:  11845908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preservation and storage techniques represent two major issues in routine cardiac surgery and heart transplantation. Historically, these methods were conceived to prevent ischemic injury to myocardium after cardiac arrest during heart operations. Evidence shows that endothelium plays a critical role in the maintenance of normal heart function after cardiac operation, mainly by controlling the coronary circulation. Methods for preservation and storage, developed initially to protect cardiomyocyte function, may be deleterious for vascular endothelium and compromise myocardial protection. In this review article the present knowledge about endothelial injury secondary to preservation and storage techniques is discussed.
Authors:
Alessandro Parolari; Patrizia Rubini; Aldo Cannata; Luigi Bonati; Francesco Alamanni; Elena Tremoli; Paolo Biglioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  73     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  682-90     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiac Surgery, University of Milan, Centro Cardiologico, Fondazione Monzino IRCCS, Italy. alessandro.parolari@cardiologicomonzino.it
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MeSH Terms
Descriptor/Qualifier:
Cardioplegic Solutions / adverse effects
Coronary Circulation / physiology
Cryopreservation
Endothelium, Vascular / physiopathology*
Heart Transplantation / physiology*
Humans
Myocardial Reperfusion Injury / physiopathology*
Organ Preservation*
Risk Factors
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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