| Endothelial cells as targets for chylomicron remnants. | |
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MedLine Citation:
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PMID: 20439166 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Endothelial dysfunction is characterised by pro-inflammatory/pro-coagulant changes in the endothelium and supports leukocyte adhesion and transmigration, key steps in early atherogenesis. There is emerging evidence that triacylglycerol-rich lipoproteins (TGRLs) present in the circulation during the postprandial phase influence vascular inflammation but the specific contribution of the remnant lipoprotein component of TGRLs is largely unexplored and the mechanistic basis of their actions poorly defined. This article provides a brief overview of the evidence supporting direct actions of these particles on endothelial cells and highlights the importance of their fatty acid composition and oxidative state as determinants of their cellular actions. |
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Authors:
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Jonathan Dalla-Riva; Elena Garonna; Jonathan Elliott; Kathleen M Botham; Caroline P Wheeler-Jones |
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Publication Detail:
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Type: Journal Article Date: 2010-05-01 |
Journal Detail:
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Title: Atherosclerosis. Supplements Volume: 11 ISSN: 1878-5050 ISO Abbreviation: Atheroscler Suppl Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973461 Medline TA: Atheroscler Suppl Country: Netherlands |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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