Document Detail

Endothelial cell function in patients with Down's syndrome.
MedLine Citation:
PMID:  15276117     Owner:  NLM     Status:  MEDLINE    
Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.
Maurizio Cappelli-Bigazzi; Giuseppe Santoro; Carmine Battaglia; Maria Teresa Palladino; Marianna Carrozza; Maria Giovanna Russo; Giuseppe Pacileo; Raffaele Calabrò
Related Documents :
2746157 - Experimental and immunohistochemical studies on the possible role of parathyroid hormon...
12945007 - The frequency of vitamin d deficiency in adults with crohn's disease.
1016827 - Primary hyperparathyroidism---a review of cases in the sheffield area.
2368437 - Intraoperative and postoperative pth secretion mode in patients with hyperparathyroidism.
16222427 - Increased pre-sma activation in early pd patients during simple self-initiated hand mov...
20567207 - Clinical presentation, treatment, and long-term outcomes in patients with takotsubo car...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  94     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2004-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-5     Citation Subset:  AIM; IM    
Division of Pediatric Cardiology, 2nd University of Medicine, Monaldi Hospital, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / administration & dosage
Analysis of Variance
Ascorbic Acid / administration & dosage
Blood Flow Velocity
Brachial Artery / physiopathology*
Case-Control Studies
Child, Preschool
Down Syndrome / complications*,  ultrasonography
Endothelial Cells
Endothelium, Vascular / drug effects,  physiopathology*,  ultrasonography
Nitroglycerin / administration & dosage
Oxidative Stress / physiology*
Reference Values
Risk Assessment
Ultrasonography, Doppler, Pulsed
Vasodilation / drug effects,  physiology*
Reg. No./Substance:
50-81-7/Ascorbic Acid; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of echocardiographic features of noncompaction of the left ventricle in adults versus idi...
Next Document:  Comparison of left ventricular function by tissue Doppler imaging in patients with diabetes mellitus...