Document Detail


Endothelial cell function in patients with Down's syndrome.
MedLine Citation:
PMID:  15276117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.
Authors:
Maurizio Cappelli-Bigazzi; Giuseppe Santoro; Carmine Battaglia; Maria Teresa Palladino; Marianna Carrozza; Maria Giovanna Russo; Giuseppe Pacileo; Raffaele Calabrò
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  94     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2004-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-5     Citation Subset:  AIM; IM    
Affiliation:
Division of Pediatric Cardiology, 2nd University of Medicine, Monaldi Hospital, Naples, Italy. mcappelli@tin.it
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / administration & dosage
Analysis of Variance
Ascorbic Acid / administration & dosage
Blood Flow Velocity
Brachial Artery / physiopathology*
Case-Control Studies
Child
Child, Preschool
Down Syndrome / complications*,  ultrasonography
Endothelial Cells
Endothelium, Vascular / drug effects,  physiopathology*,  ultrasonography
Female
Humans
Male
Nitroglycerin / administration & dosage
Oxidative Stress / physiology*
Probability
Reference Values
Risk Assessment
Ultrasonography, Doppler, Pulsed
Vasodilation / drug effects,  physiology*
Chemical
Reg. No./Substance:
50-81-7/Ascorbic Acid; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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