Document Detail


Endothelial cell damage in primary biliary cirrhosis: influence of cholestasis and immunological mechanisms.
MedLine Citation:
PMID:  1395104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a study looking for evidence of endothelial cell damage in primary biliary cirrhosis, serum from patients was found to be significantly more cytotoxic to cultured endothelial cells in vitro than normal control serum (P less than 0.001). Serum also contained higher levels of von Willebrand factor antigen (vWFAg, a specific product of the endothelium) than control serum (P less than 0.001). Cytotoxicity correlated with serum levels of vWFAg (P less than 0.05) and with serum bilirubin (P less than 0.05). No correlations were found between cytotoxicity and circulating immune complexes, C-reactive protein or CH50. The study was controlled by serum from patients with other liver diseases. In these samples vWFAg (P less than 0.003), and bilirubin levels (P less than 0.001) were also raised relative to normal controls. vWFAg levels again correlated with levels of bilirubin (P less than 0.05). Tissue culture experiments showed that purified bilirubin was cytotoxic to human umbilical vein endothelial cells and induced the release of vWFAg. The case report of a patient with obstructive jaundice again indicated that levels of bilirubin and vWFAg were related. These results suggest that endothelial cell damage occurs in both primary biliary cirrhosis and to a lesser extent in other liver diseases, and may be mediated by cholestasis, not by humoral immunological mechanisms.
Authors:
A D Blann; C Babbs; J M Neuberger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  90     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-05     Completed Date:  1992-11-05     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Affiliation:
University Department of Surgery, University Hospital of South Manchester, Didsbury, UK.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood,  pharmacology*
Cell Survival / drug effects
Cholestasis / blood
Endothelium, Vascular / pathology*
Humans
Liver Cirrhosis, Biliary / blood*,  pathology
von Willebrand Factor / metabolism*
Chemical
Reg. No./Substance:
0/von Willebrand Factor; 635-65-4/Bilirubin
Comments/Corrections

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