| Endothelial cell changes in acute hepatitis. A light and electron microscopic study. | |
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MedLine Citation:
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PMID: 6502298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatic endothelial cells were studied by light and electron microscopy in 48 patients with acute hepatitis due to virus infection or drug idiosyncrasy. Light microscopy revealed cell swelling and appearance of dense refractile intracytoplasmic granules staining with the amylase PAS reaction and for iron by Perls' method. They were orcein-negative. These cells, regarded as 'activated' endothelial cells, were found throughout the parenchyma, especially in the classical form of acute hepatitis. In acute hepatitis with bridging, panacinar or periportal necrosis, activated endothelial cells were prominent in the necrotic areas. They were constantly seen lining newly formed capillaries in these sites. By electron microscopy, the intracytoplasmic granules had the characteristics of primary or secondary siderosomes. In areas of capillarization, basement membrane material was seen on the aspect of the activated cells facing the space of Disse. Activated endothelial cells may play a part in protecting hepatocytes from injury. |
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Authors:
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K A Bardadin; P J Scheuer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 144 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-01-14 Completed Date: 1985-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 213-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Basement Membrane / ultrastructure Cytoplasmic Granules / ultrastructure Endothelium / ultrastructure Hepatitis / pathology* Humans Liver / ultrastructure* Macrophages / ultrastructure Microscopy, Electron |
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