Document Detail

Endothelial cell activation in muscle biopsy samples is related to clinical severity in human cerebral malaria.
MedLine Citation:
PMID:  9878034     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis of vascular sequestration of parasitized erythrocytes in Plasmodium falciparum malaria in vivo, a pathologic and immunohistochemical study was done of the microvasculature of skeletal muscle biopsy samples from P. falciparum malaria patients at different stages of severity. Parasitized red blood cells sequestered in the skeletal muscle vessels were observed in samples from necropsies but were never demonstrated in biopsy specimens. Vascular cell adhesion molecule-1 and E-selectin expression was consistent only in specimens from cerebral malaria patients. Samples from such patients had strong staining of the constitutive endothelial adhesion molecules tested. The staining intensity gradually decreased in samples from persons with milder forms of the disease. Four of 13 patients with severe malaria had aggregates of red blood cells, occasionally parasitized inside the muscle fibers. These data suggest that skeletal muscle biopsy could be a useful model for the study of the pathogenesis of malaria in vivo.
F García; M Cebrián; M Dgedge; J Casademont; J L Bedini; O Neves; X Filella; M Cinta Cid; M Corachán; J M Grau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  179     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  475-83     Citation Subset:  AIM; IM    
Infectious Diseases Unit, Hospital Clinic, 08036, Barcelona, Spain.
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MeSH Terms
Cell Aggregation
Endothelium, Vascular / physiopathology*
Erythrocytes / pathology
Leukocytes, Mononuclear
Macrophages / pathology
Malaria, Cerebral / pathology,  physiopathology*
Middle Aged
Muscle, Skeletal / blood supply,  metabolism,  pathology*

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