Document Detail


Endothelial cell activation in muscle biopsy samples is related to clinical severity in human cerebral malaria.
MedLine Citation:
PMID:  9878034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis of vascular sequestration of parasitized erythrocytes in Plasmodium falciparum malaria in vivo, a pathologic and immunohistochemical study was done of the microvasculature of skeletal muscle biopsy samples from P. falciparum malaria patients at different stages of severity. Parasitized red blood cells sequestered in the skeletal muscle vessels were observed in samples from necropsies but were never demonstrated in biopsy specimens. Vascular cell adhesion molecule-1 and E-selectin expression was consistent only in specimens from cerebral malaria patients. Samples from such patients had strong staining of the constitutive endothelial adhesion molecules tested. The staining intensity gradually decreased in samples from persons with milder forms of the disease. Four of 13 patients with severe malaria had aggregates of red blood cells, occasionally parasitized inside the muscle fibers. These data suggest that skeletal muscle biopsy could be a useful model for the study of the pathogenesis of malaria in vivo.
Authors:
F García; M Cebrián; M Dgedge; J Casademont; J L Bedini; O Neves; X Filella; M Cinta Cid; M Corachán; J M Grau
Related Documents :
24495754 - Integrin activation and internalization mediated by extracellular matrix elasticity: a ...
22949384 - Celastrol attenuates adipokine resistin-associated matrix interaction and migration of ...
25122554 - Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosi...
11278674 - Quantifying the impact of membrane microtopology on effective two-dimensional affinity.
16518864 - Electrochemical high-content screening of nitric oxide release from endothelial cells.
24495754 - Integrin activation and internalization mediated by extracellular matrix elasticity: a ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  179     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  475-83     Citation Subset:  AIM; IM    
Affiliation:
Infectious Diseases Unit, Hospital Clinic, 08036, Barcelona, Spain. fgarcia@medicina.ub.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biopsy
Cell Aggregation
Child
Endothelium, Vascular / physiopathology*
Erythrocytes / pathology
Female
Humans
Leukocytes, Mononuclear
Macrophages / pathology
Malaria, Cerebral / pathology,  physiopathology*
Male
Middle Aged
Muscle, Skeletal / blood supply,  metabolism,  pathology*
Oxidation-Reduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells ...
Next Document:  Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow tr...