Document Detail

Endothelial activation microparticles and inflammation status improve with exercise training in african americans.
MedLine Citation:
PMID:  23691280     Owner:  NLM     Status:  PubMed-not-MEDLINE    
African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing. Participants engaged in 6 months of AEXT. Following the AEXT intervention, all baseline tests were repeated. FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT. Changes in inflammatory biomarkers did not significantly predict the change in FMD. The change in VO2 max significantly predicted the change in IL-10. Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans.
Dianne M Babbitt; Keith M Diaz; Deborah L Feairheller; Kathleen M Sturgeon; Amanda M Perkins; Praveen Veerabhadrappa; Sheara T Williamson; Jan Kretzschmar; Chenyi Ling; Hojun Lee; Heather Grimm; Sunny R Thakkar; Deborah L Crabbe; Mohammed A Kashem; Michael D Brown
Publication Detail:
Type:  Journal Article     Date:  2013-04-18
Journal Detail:
Title:  International journal of hypertension     Volume:  2013     ISSN:  2090-0384     ISO Abbreviation:  Int J Hypertens     Publication Date:  2013  
Date Detail:
Created Date:  2013-05-21     Completed Date:  2013-05-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101538881     Medline TA:  Int J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538017     Citation Subset:  -    
Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USA.
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