Document Detail

Endothelial Progenitor Cells in Mothers of Low-Birthweight Infants: A Link between Defective Placental Vascularization and Increased Cardiovascular Risk?
MedLine Citation:
PMID:  23162106     Owner:  NLM     Status:  Publisher    
Context:Offspring birthweight is inversely associated with future maternal cardiovascular mortality, a relationship that has yet to be fully elucidated. Endothelial progenitor cells (EPCs) are thought to play a key role in vasculogenesis, and EPC numbers reflect cardiovascular risk.Objective:Our objective was to ascertain whether EPC number or function was reduced in mothers of low-birthweight infants.Design and Setting:This was a prospective cohort study in a general antenatal department of a university maternity hospital.Participants:Twenty-three mothers of small for gestational age (SGA) infants (birthweight < 10th centile) and 23 mothers of appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile) were recruited.Main Outcome Measures:Maternal EPC number and function, conventional cardiovascular risk markers, and cord blood adiponectin were measured.Results:Median EPC count was lower (294 vs. 367, P = 0.005) and EPC migration was reduced (0.91 vs. 1.59, P < 0.001) in SGA compared with AGA infants, with no difference in EPC adhesion (0.221 vs. 0.284 fluorescence units, P = 0.257). Maternal triglyceride levels were higher in SGA than AGA infants (0.98 vs. 0.78 mmol/liter, P = 0.006), but there was no difference in cholesterol, glucose, insulin, glycosylated hemoglobin, adiponectin, or blood pressure. There was a moderate monotone (increasing) relationship between birthweight and umbilical cord blood adiponectin (r = 0.475, P = 0.005).Conclusion:Giving birth to an SGA infant was associated with lower maternal EPC number and reduced migratory function. Cord blood adiponectin was significantly correlated with birthweight.
Thomas F J King; David A Bergin; Etaoin M Kent; Fiona Manning; Emer P Reeves; Patrick Dicker; Noel G McElvaney; Seamus Sreenan; Fergal D Malone; John H McDermott
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Endocrinology (T.F.J.K., S.S., J.H.M.), Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, Ireland; Department of Medicine (D.A.B., E.P.R., N.G.M.), Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland; and Department of Obstetrics and Gynaecology (F.M., P.D., F.D.M., E.M.K.), Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin 1, Ireland.
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