Document Detail

Endothelial Progenitor Cells in Acute Myocardial Infarction and Sleep Disordered Breathing.
MedLine Citation:
PMID:  23155141     Owner:  NLM     Status:  Publisher    
RATIONALE: Mobilization and functions of endothelial progenitor cells (EPCs) are increased in acute myocardial infarction (AMI) patients. Yet, sleep disordered breathing (SDB) is highly prevalent in AMI patients. OBJECTIVE: To compare EPCs numbers and functions in AMI patients with SDB (AMI-SDB) and without SDB (AMI-only) and to determine the effects of intermittent hypoxia (IH) in-vitro on EPCs proliferative and angiogenic properties. METHODS: Forty male AMI patients underwent a whole-night sleep study using ambulatory monitoring. Nineteen had SDB (oxygen desaturation index >5 events/hour). AMI-SDB and AMI-only patients were matched by age, BMI, blood chemistry and co-morbidities. Blood samples were analyzed by flow cytometry, endothelial cell colony-forming-units (EC-CFUs), paracrine measures, blood chemistry, and oxidative stress, inflammatory and angiogenic markers. Effects of IH in-vitro were studied in twelve healthy subjects. MEASUREMENTS AND MAIN RESULTS: Circulating EPCs (CD34+/ KDR+), angiogenic T cells (CD3+/CD31+/CXCR4+) and vascular endothelial growth factor (VEGF) in monocytes were significantly higher in AMI-SDB patients while plasma stromal cell-derived factor (SDF)-1α levels were significantly lower. Also, EC-CFUs numbers and EC-CFUs paracrine effects on endothelial tube formation were significantly higher in AMI-SDB compared to AMI-only patients. Similarly, in cell cultures from healthy subjects, EC-CFUs numbers and their paracrine effects on endothelial tube formation were increased after exposure to IH in-vitro, compared to normoxia. CONCLUSIONS: Co-existent mild-moderate SDB in AMI patients increased the mobilization, proliferative and angiogenic capacities of EPCs, angiogenic T cells numbers and VEGF expression in monocytes, compared to AMI patients without SDB. IH in-vitro had similar effects on healthy EPCs functions.
Slava Berger; Doron Aronson; Peretz Lavie; Lena Lavie
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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