| Endothelial NF-κB in Obesity and Aging: Is Endothelial NF-κB a Master Regulator of Inflammation and Insulin Resistance? | |
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MedLine Citation:
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PMID: 22302839 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Insulin resistance is a major characteristic of type 2 diabetes and develops in multiple organs including skeletal muscle, liver, adipose tissue, and heart(1). Insulin resistance is caused by obesity and therefore establishes an important causal relationship between obesity and type 2 diabetes(2). Insulin resistance also develops in aging, but this process is less well understood. Obesity is a complex physiological state with alterations in lipid metabolism, dysregulated production of hormones, ectopic accumulation of fat, mitochondrial dysfunction, and chronic low-grade inflammation(3,4). All of these abnormalities may independently cause insulin resistance and affect glucose homeostasis, which make insulin resistance as equally complex as obesity itself. (SELECT FULL TEXT TO CONTINUE). |
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Authors:
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Jason K Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Circulation Volume: - ISSN: 1524-4539 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Massachusetts Medical School, Worcester, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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