Document Detail

Endothelial function and arterial compliance are not impaired in subjects with heart failure of non-ischemic origin.
MedLine Citation:
PMID:  20142022     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with heart failure and underlying ischemic heart disease (IHD) exhibit both endothelial dysfunction and increased arterial stiffness. We investigated whether this is also the case in heart failure of nonischemic etiology. METHODS AND RESULTS: Eleven patients with heart failure and IHD, 12 patients with heart failure from angiographically verified idiopathic nonischemic dilated cardiomyopathy (DCM), and 16 healthy subjects of similar age and sex were compared. Endothelium-dependent and independent function were evaluated by ultrasonic measurement of flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)-induced dilatation of the brachial artery respectively. Vascular compliance was assessed by carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx). Heart failure severity was similar in IHD and DCM patients. FMD was impaired in the subjects with IHD as compared with control subjects (4.8 +/- 0.3 vs. 8.0 +/- 3.6 %, P < .01), but not in those with DCM. GTN-induced vasodilatation was not different in patients and controls. PWV was also increased in IHD patients compared with controls (12.1 +/- 3.6 vs. 8.0 +/- 1.6 m/s, P < .01), but not in DCM patients. AIx was similar in patients and controls. CONCLUSION: Heart failure of nonischemic etiology is not associated with abnormalities of endothelium-mediated dilatation or of arterial compliance. The findings of our study now need to be confirmed in larger studies.
Ashish Shah; Eugenia Gkaliagkousi; James M Ritter; Albert Ferro
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-14
Journal Detail:
Title:  Journal of cardiac failure     Volume:  16     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Clinical Pharmacology, Cardiovascular Division, School of Medicine, King's College London, London, UK.
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MeSH Terms
Carotid Artery, Common / physiology*,  ultrasonography*
Endothelium, Vascular / physiology*,  ultrasonography*
Heart Failure / physiopathology,  ultrasonography*
Middle Aged
Myocardial Ischemia / physiopathology,  ultrasonography*
Vasodilation / physiology

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