| Endothelial dysfunction in systemic lupus erythematosus: evaluation with 13N-ammonia PET. | |
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MedLine Citation:
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PMID: 21078786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %ΔMBF, and myocardial flow reserve (MFR) were calculated. RESULTS: There were 16 women in the SLE group (mean age ± SD, 31.4 ± 8.3 y) and 16 women in the healthy control group (31.5 ± 11.1 y). Mean endothelium-dependent vasodilatation index and %ΔMBF were significantly lower in SLE patients (1.18 ± 0.55 vs. 1.63 ± 0.65, P = 0.04, and 18 ± 55 vs. 63 ± 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 ± 0.59 vs. 2.73 ± 0.77, P = 0.20). CONCLUSION: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients. |
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Authors:
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Erick Alexánderson; Juan M Ochoa; Rodrigo Calleja; Juan G Juárez-Rojas; John O Prior; Rodrigo Jácome; Edgar Romero; Aloha Meave; Carlos Posadas-Romero |
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Publication Detail:
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Type: Journal Article Date: 2010-11-15 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1927-31 Citation Subset: IM |
Affiliation:
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Department of Nuclear Cardiology and Cardiac Imaging, Instituto Nacional de Cardiología Ignacio Chávez, México City, México. alexanderick@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ammonia / diagnostic use* Cold Temperature / diagnostic use Coronary Artery Disease / etiology, pathology, radionuclide imaging Coronary Circulation / physiology Endothelium, Vascular / metabolism, physiopathology*, radionuclide imaging* Female Hemodynamics / physiology Humans Image Interpretation, Computer-Assisted Lupus Erythematosus, Systemic / metabolism, physiopathology*, radionuclide imaging* Nitrogen Radioisotopes / diagnostic use Positron-Emission Tomography Pressure Radiopharmaceuticals / diagnostic use* Stress, Psychological / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Radioisotopes; 0/Radiopharmaceuticals; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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