Document Detail

Endosulfan effects on pituitary hormone and both nitrosative and oxidative stress in pubertal male rats.
MedLine Citation:
PMID:  20471459     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level. Endosulfan was administered orally at the doses of 0.61 mg/kg/day or 6.12 mg/kg/day, and possible toxic effects were studied in pubertal male pups (at postnatal day 30). Gene expression was evaluated by RT-PCR and plasma hormone levels by RIA. Exposure to both administered doses down-regulated LH, GH and TSH. Treatment with 0.61 mg endosulfan/kg/day decreased prolactin expression, although its plasmatic concentration was decreased by both administered doses. LH secretion was stimulated by both doses, whereas the highest dose increased GH levels and decreased plasma TSH concentration. Endosulfan up-regulated NOS1 and NOS2. We can conclude that in pubertal male rat, prenatal and lactational exposure to endosulfan modifies expression and release of prolactin, LH, GH and TSH, and pituitary NOS1 and NOS2 mRNA levels, suggesting that nitrosative stress can be implicated in the endocrine toxicity of endosulfan at pituitary level.
A Caride; A Lafuente; T Cabaleiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-13
Journal Detail:
Title:  Toxicology letters     Volume:  197     ISSN:  1879-3169     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Laboratorio de Toxicología, Facultad de Ciencias, Universidad de Vigo, Campus de Orense, Las Lagunas, 32004 Orense, Spain.
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MeSH Terms
Dose-Response Relationship, Drug
Endosulfan / pharmacology,  toxicity*
Gene Expression Regulation / drug effects*
Heme Oxygenase-1 / genetics,  metabolism
Insecticides / pharmacology,  toxicity*
Nitric Oxide Synthase / genetics,  metabolism
Nitrosation / drug effects
Oxidative Stress / drug effects
Pituitary Hormones / metabolism*
Prenatal Exposure Delayed Effects
RNA, Messenger / metabolism
Sexual Maturation*
Stress, Physiological / drug effects*
Reg. No./Substance:
0/Insecticides; 0/Pituitary Hormones; 0/RNA, Messenger; 115-29-7/Endosulfan; EC Oxide Synthase; EC Oxygenase-1

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