| Endosonographic and color Doppler flow imaging alterations observed within irradiate rectal cancer. | |
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MedLine Citation:
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PMID: 8635946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To correlate the endosonographic and color Doppler flow imaging alterations observed in irradiated rectal cancers with the pathologic features of radiation response, and to evaluate the potential impact of altered blood flow on the integrity of the surgical anastomosis. METHODS AND MATERIALS: Endosonography with color and pulsed wave Doppler was performed on 20 rectal cancer masses before and after high dose preoperative radiation (XRT). Pre- and post-XRT observations included comparing alterations in tumor size, sonographic echotexture, color Doppler flow, and pulsatility indices. Comparisons were made with pathologic findings in the irradiated specimens and with the incidence of anastomotic failure. RESULTS: Compared to pre-XRT observations, irradiated rectal cancers decreased in size and became either mixed in echogenicity with less apparent color Doppler flow (16 of 20) or unchanged in color Doppler flow and echotexture (4 of 20). Those with less flow (16 of 20) were imaged later (mean = 90.2 +/- 12.1 days) than those without change in color Doppler flow (mean = 21.7 +/- 2.7 days). Pathologically, the group of four without change in color Doppler signal had features of acute inflammation which were not observed in 16 of 20 imaged later. Based on pulsatility index measurements, both high and low resistance vessels were detected and confirmed by immunohistochemical staining, and features of postradiation obliterative vasculitis were observed. Only one primary anastomosis in 14 patients with decreased flow failed. CONCLUSIONS: The sonographic and color Doppler flow imaging alterations observed within irradiated rectal cancer correlated with changes of postradiation obliterative vasculitis. The apparent diminished local blood flow within high and low resistance vessels post-XRT did not result in an increased incidence of anastomotic failures. |
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Authors:
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A A Alexander; J P Palazzo; N R Ahmad; J B Liu; F Forsberg; J Marks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 35 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-07-10 Completed Date: 1996-07-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 369-75 Citation Subset: IM |
Affiliation:
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Department of Radiology, Jefferson Medical College, Philadelphia, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Female Humans Male Middle Aged Rectal Neoplasms / blood supply*, pathology, radiotherapy*, ultrasonography Regional Blood Flow Ultrasonography, Doppler, Color |
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