| Endosomes, exosomes and Trojan viruses. | |
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MedLine Citation:
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PMID: 15223058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retroviruses are enveloped viruses that are generally assumed to bud at the plasma membrane of infected cells. Recently it has become apparent that some of these viruses use the endocytic pathway to coordinate their assembly and release. In addition, these and some other enveloped viruses exploit the machinery that generates the internal membranes of multivesicular bodies (MVB). These observations and others have led to the suggestion that retroviruses be regarded as "viral exosomes". Here we discuss this concept and the emerging evidence that compartments of the endocytic pathway play important roles in the biogenesis of both the internal vesicles of MVB and viruses. |
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Authors:
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Annegret Pelchen-Matthews; Graça Raposo; Mark Marsh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in microbiology Volume: 12 ISSN: 0966-842X ISO Abbreviation: Trends Microbiol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-29 Completed Date: 2004-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 310-6 Citation Subset: IM |
Affiliation:
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Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. a.pelchen-matthews@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Compartmentation Cytoplasmic Vesicles / metabolism, virology Endocytosis* Endosomes / metabolism*, virology Exocytosis Gene Products, env / metabolism Gene Products, gag / metabolism RNA, Viral / metabolism Retroviridae / growth & development, physiology* Virus Assembly* |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, env; 0/Gene Products, gag; 0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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